摘要:

High-precision large dynamic-range (DR) current-sensing front-ends are widely used in biomedical applications, such as patch-clamp, molecular concentration detection, and gene sequencing. The new gene sequencers require low-noise analog front-ends capable of sensing large DR current (>100 dB) down to sub-pA-level. At this level of precision, oversampled data converters are usually used. However, given the limited oversampling ratio in high throughput applications, it is very challenging to achieve a sub-pA-level sensitivity and >100dB DR within the limited area and energy budgets [1]. In [2], a 140dB DR is achieved using a multi-bit delta-sigma modulator (DSM), but the power consumption is over 1mW and the current sensitivity is limited to 6.3pA. An hourglass ADC achieving a 100fA sensitivity and 140dB DR is presented in [3], but is limited by conversion rate and relatively high power consumption (295μW). For a 100Hz bandwidth, its noise floor increases to 18pA.

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