摘要:

{BACKGROUND: Whole-body and thoracic ionizing radiation exposure are both associated with the development of renal dysfunction. However, whether low-level environmental radiation from air pollution affects renal function remains unknown. OBJECTIVES: We investigated the association of particle radioactivity (PR) with renal function defined by the estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) in the Normative Aging Study. METHODS: This longitudinal analysis included 2491 medical visits from 809 white males enrolled between 1999 and 2013. The eGFR was calculated using the CKD-EPI and MDRD equations, and CKD cases were identified as those with an eGFR <60mL/min/1.73m(2). Gross beta activity measured by five monitors of the U.S. Environmental Protection Agency's RadNet monitoring network was utilized to represent PR. RESULTS: Ambient PR levels from 1 to 28days prior to clinical visit demonstrated robust negative associations with both forms of eGFR, but not with the increased odds of CKD. An interquartile range higher 28-day average ambient PR level was significantly associated with 0.83-mL/min/1.73m(2) lower eGFR estimated by the CKD-EPI equation (95% confidence interval: -1.46, -0.20

附注:

Gao, Xu Koutrakis, Petros Blomberg, Annelise J Coull, Brent Vokonas, Pantel Schwartz, Joel Baccarelli, Andrea A eng P30 ES009089/ES/NIEHS NIH HHS/ R01 ES021733/ES/NIEHS NIH HHS/ R01 ES025225/ES/NIEHS NIH HHS/ R01 ES027747/ES/NIEHS NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Netherlands Environ Int. 2019 Oct;131:105018. doi: 10.1016/j.envint.2019.105018. Epub 2019 Jul 20.

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