摘要:
Polycyclic aromatic hydrocarbons (PAH) are ubiquitous air pollutants associated with negative impacts on growth, development and behavior in children. Source-specific biological markers of PAH exposure are needed for targeting interventions to protect children. Nitro-derivatives of PAH can act as markers of exposure to diesel exhaust, gasoline exhaust, or general combustion sources. Using a novel HPLC-APCI-MS/MS detection method, we examined four hemoglobin (Hb) adducts of nitro-PAH metabolites and the Hb adduct of a benzo[a]pyrene (BaP) metabolite in 22 umbilical cord blood samples. The samples were collected from a birth cohort with comprehensive data on prenatal PAH exposure, including prenatal personal air monitoring and DNA adducts in maternal and umbilical cord blood. Using non-parametric analyses, heat maps, and principal component analysis (PCA), we analyzed the relationship between the five Hb adducts and previous PAH measurements, with each measurement representing a different duration of exposure. We found that Hb adducts derived from several diesel-related nitro-PAHs (2-nitrofluorene and 1-nitropyrene) were significantly correlated (r = 0.77, p 附注:
Wheelock, KylieZhang, Junfeng JimMcConnell, RobTang, DeliangVolk, Heather EWang, YaHerbstman, Julie BWang, ShuangPhillips, David HCamann, DavidGong, JichengPerera, FredericaengP01 ES009600/ES/NIEHS NIH HHS/P01 ES022845/ES/NIEHS NIH HHS/R01 ES008977/ES/NIEHS NIH HHS/EnglandEnviron Sci Process Impacts. 2018 Mar 21. doi: 10.1039/C7EM00522A.
