<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wheelock, K.</style></author><author><style face="normal" font="default" size="100%">J.J. Zhang</style></author><author><style face="normal" font="default" size="100%">McConnell, R.</style></author><author><style face="normal" font="default" size="100%">Tang, D.</style></author><author><style face="normal" font="default" size="100%">Volk, H. E.</style></author><author><style face="normal" font="default" size="100%">Y. Wang</style></author><author><style face="normal" font="default" size="100%">Herbstman, J. B.</style></author><author><style face="normal" font="default" size="100%">S. Wang</style></author><author><style face="normal" font="default" size="100%">Phillips, D. H.</style></author><author><style face="normal" font="default" size="100%">Camann, D.</style></author><author><style face="normal" font="default" size="100%">Gong, J.</style></author><author><style face="normal" font="default" size="100%">Perera, F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons</style></title><secondary-title><style face="normal" font="default" size="100%">Environ Sci Process Impacts</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Environ Sci-Proc ImpEnviron Sci-Proc Imp</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">air</style></keyword><keyword><style  face="normal" font="default" size="100%">atmospheric reactions</style></keyword><keyword><style  face="normal" font="default" size="100%">benzo(a)pyrene</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA-adducts</style></keyword><keyword><style  face="normal" font="default" size="100%">emissions</style></keyword><keyword><style  face="normal" font="default" size="100%">exhaust</style></keyword><keyword><style  face="normal" font="default" size="100%">exposure</style></keyword><keyword><style  face="normal" font="default" size="100%">fluorometric assay</style></keyword><keyword><style  face="normal" font="default" size="100%">PAH</style></keyword><keyword><style  face="normal" font="default" size="100%">particulate matter</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Mar 21</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">5</style></number><edition><style face="normal" font="default" size="100%">2018/03/22</style></edition><volume><style face="normal" font="default" size="100%">20</style></volume><pages><style face="normal" font="default" size="100%">780-789</style></pages><isbn><style face="normal" font="default" size="100%">2050-7895 (Electronic)2050-7887 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">Polycyclic aromatic hydrocarbons (PAH) are ubiquitous air pollutants associated with negative impacts on growth, development and behavior in children. Source-specific biological markers of PAH exposure are needed for targeting interventions to protect children. Nitro-derivatives of PAH can act as markers of exposure to diesel exhaust, gasoline exhaust, or general combustion sources. Using a novel HPLC-APCI-MS/MS detection method, we examined four hemoglobin (Hb) adducts of nitro-PAH metabolites and the Hb adduct of a benzo[a]pyrene (BaP) metabolite in 22 umbilical cord blood samples. The samples were collected from a birth cohort with comprehensive data on prenatal PAH exposure, including prenatal personal air monitoring and DNA adducts in maternal and umbilical cord blood. Using non-parametric analyses, heat maps, and principal component analysis (PCA), we analyzed the relationship between the five Hb adducts and previous PAH measurements, with each measurement representing a different duration of exposure. We found that Hb adducts derived from several diesel-related nitro-PAHs (2-nitrofluorene and 1-nitropyrene) were significantly correlated (r = 0.77, p &lt;/= 0.0001) and grouped together in PCA. Nitro-PAH derived Hb adducts were largely unrelated to previously collected measures of exposure to a number of PAH parent compounds. These measures need to be validated in a larger sample.</style></abstract><accession-num><style face="normal" font="default" size="100%">29561551</style></accession-num><notes><style face="normal" font="default" size="100%">Wheelock, KylieZhang, Junfeng JimMcConnell, RobTang, DeliangVolk, Heather EWang, YaHerbstman, Julie BWang, ShuangPhillips, David HCamann, DavidGong, JichengPerera, FredericaengP01 ES009600/ES/NIEHS NIH HHS/P01 ES022845/ES/NIEHS NIH HHS/R01 ES008977/ES/NIEHS NIH HHS/EnglandEnviron Sci Process Impacts. 2018 Mar 21. doi: 10.1039/C7EM00522A.</style></notes><auth-address><style face="normal" font="default" size="100%">Columbia Center for Children's Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W. 168th St., 12th Floor, New York, NY 10032, USA. fpp1@cumc.columbia.edu.Nicholas School of the Environment, Duke Global Health Institute, Duke University, LSRC Room A309, 308 Research Drive, Durham, NC 27708, USA. junfeng.zhang@duke.edu.Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USA.Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, USA.Columbia Center for Children's Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W. 168th St., 12th Floor, New York, NY 10032, USA. fpp1@cumc.columbia.edu and Department of Biostatistics, Mailman School of Public Health, Columbia University, USA.Department of Analytical, Environmental &amp; Forensic Sciences, Environmental Toxicology Group, MRC-PHE Centre for Environment &amp; Health, NIHR Health Protection Research Unit in Health Impact of Environmental Hazards, King's College London, UK.Chemistry and Chemical Engineering Division, Southwest Research Institute, USA.Nicholas School of the Environment, Duke Global Health Institute, Duke University, LSRC Room A309, 308 Research Drive, Durham, NC 27708, USA. junfeng.zhang@duke.edu and College of Environmental Sciences and Engineering &amp; BIC-ESAT, Peking University, Beijing, China.</style></auth-address></record></records></xml>