@article {18205,
	title = {A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons},
	journal = {Environ Sci Process Impacts},
	volume = {20},
	number = {5},
	year = {2018},
	note = {Wheelock, KylieZhang, Junfeng JimMcConnell, RobTang, DeliangVolk, Heather EWang, YaHerbstman, Julie BWang, ShuangPhillips, David HCamann, DavidGong, JichengPerera, FredericaengP01 ES009600/ES/NIEHS NIH HHS/P01 ES022845/ES/NIEHS NIH HHS/R01 ES008977/ES/NIEHS NIH HHS/EnglandEnviron Sci Process Impacts. 2018 Mar 21. doi: 10.1039/C7EM00522A.},
	month = {Mar 21},
	pages = {780-789},
	edition = {2018/03/22},
	abstract = {Polycyclic aromatic hydrocarbons (PAH) are ubiquitous air pollutants associated with negative impacts on growth, development and behavior in children. Source-specific biological markers of PAH exposure are needed for targeting interventions to protect children. Nitro-derivatives of PAH can act as markers of exposure to diesel exhaust, gasoline exhaust, or general combustion sources. Using a novel HPLC-APCI-MS/MS detection method, we examined four hemoglobin (Hb) adducts of nitro-PAH metabolites and the Hb adduct of a benzo[a]pyrene (BaP) metabolite in 22 umbilical cord blood samples. The samples were collected from a birth cohort with comprehensive data on prenatal PAH exposure, including prenatal personal air monitoring and DNA adducts in maternal and umbilical cord blood. Using non-parametric analyses, heat maps, and principal component analysis (PCA), we analyzed the relationship between the five Hb adducts and previous PAH measurements, with each measurement representing a different duration of exposure. We found that Hb adducts derived from several diesel-related nitro-PAHs (2-nitrofluorene and 1-nitropyrene) were significantly correlated (r = 0.77, p ,
	keywords = {air, atmospheric reactions, benzo(a)pyrene, DNA-adducts, emissions, exhaust, exposure, fluorometric assay, PAH, particulate matter},
	isbn = {2050-7895 (Electronic)2050-7887 (Linking)},
	author = {Wheelock, K. and J.J. Zhang and McConnell, R. and Tang, D. and Volk, H. E. and Y. Wang and Herbstman, J. B. and S. Wang and Phillips, D. H. and Camann, D. and Gong, J. and Perera, F.}
}
