摘要:

{BACKGROUND: Methylation quantitative trait loci (mQTLs) are the genetic variants that may affect the DNA methylation patterns of CpG sites. However, their roles in influencing the disturbances of smoking-related epigenetic changes have not been well established. This study was conducted to address whether mQTLs exist in the vicinity of smoking-related CpG sites (+/- 50 kb) and to examine their associations with smoking exposure and all-cause mortality in older adults. RESULTS: We obtained DNA methylation profiles in whole blood samples by Illumina Infinium Human Methylation 450 BeadChip array of two independent subsamples of the ESTHER study (discovery set

附注:

Gao, Xu Thomsen, Hauke Zhang, Yan Breitling, Lutz Philipp Brenner, Hermann eng Research Support, Non-U.S. Gov't Germany Clin Epigenetics. 2017 Aug 17;9:87. doi: 10.1186/s13148-017-0387-6. eCollection 2017.

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