In order to control regional acid deposition pollution, it is necessary to determine scientific regional control targets for atmospheric acid deposition. This study proposed a method to conduct multi-site simulation using the VSD model and the simulation results were plotted by cumulative frequency distribution curves. Then the regional acid deposition control targets were determined based on the analysis of the restoration of the soil in the region under different deposition scenarios in the target years. The method was applied in the Guangzhou-Dongguan-Huizhou region. To analyze the control targets for acid deposition in this region, 25 sites were simulated by VSD model based on onsite soil sampling and investigation, and the results were plotted by cumulative frequency distribution curves. The results indicated that when S deposition was controlled alone and if the protection rate was 80%, the S control targets should be 7.68-12g.m-2.yr-1 in the short-term and 10.24-16g.m-2.yr-1 in the long-term; the short-term and long-term S deposition control targets should be 5.12-8g.m-2 .yr-1 和7.68-12g.m-2 .yr-1 if the protection rate was 95%. When the S and BC depositions were controlled simultaneously and if the protection rate was 80%, the S control targets should be 2.56-4 g.m-2 .yr-1 in the short-term and 5.12-8 g.m-2 .yr-1 in the long-term when BC deposition was 6.4-12.8 g.m-2 .yr -1 ; and the S control targets should be 2.56-4 g.m-2.yr-1 when BC deposition was 4.8-9.6 g.m-2.yr-1. If the protection rate was 95%, the S control targets should be 0.64-1 g.m-2.yr-1 in the short-term and 5.12-8 g.m-2.yr-1 in the long-term when BC deposition was 6.4-12.8 g.m-2.yr-1; and the S control targets should be 0.64-1g.m-2.yr-1 in the short-term and 2.56-4g.m-2.yr-1 in the long-term. When BC deposition was 2-4 g.m-2.yr-1, S deposition should be controlled to 0.64-1g.m-2.yr-1 for the protection rate of 80% and 95%, and some manual restoration measures are required at the same time