科研成果

2011
Zhang M, Lin S, Song X, Liu J, Fu Y, Ge X, Fu X, Chang Z, Chen PR. A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance. Nature Chemical Biology [Internet]. 2011;(10):671-677. 访问链接
Hao Z, Hong S, Chen X, Chen PR. Introducing bioorthogonal functionalities into proteins in living cells. Accounts of Chemical Research [Internet]. 2011;(9):742-751. 访问链接
Ai H-wang, Shen W, Sagi A, Chen PR, Schultz PG. Probing Protein-Protein Interactions with a Genetically Encoded Photo-crosslinking Amino Acid. ChemBioChem [Internet]. 2011;(12):1854-1857. 访问链接
Hao Z, Song Y, Lin S, Yang M, Liang Y, Wang J, Chen PR. A readily synthesized cyclic pyrrolysine analogue for site-specific protein "click" labeling. Chemical Communications [Internet]. 2011;(15):4502-4504. 访问链接
Chen PR, Brugarolas P, He C. Redox signaling in human pathogens. Antioxidants and Redox Signaling [Internet]. 2011;(6):1107-1118. 访问链接
Lin S, Zhang Z, Xu H, Li L, Chen S, Li J, Hao Z, Chen PR. Site-specific incorporation of photo-cross-linker and bioorthogonal amino acids into enteric bacterial pathogens. Journal of the American Chemical Society [Internet]. 2011;(50):20581-20587. 访问链接
2010
Groff D, Chen PR, Peters FB, Schultz PG. A genetically encoded e-N-Methyl lysine in mammalian cells. ChemBioChem [Internet]. 2010;(8):1066-1068. 访问链接
Zhao BS, Liang Y, Song Y, Zheng C, Hao Z, Chen PR. A highly selective fluorescent probe for visualization of organic hydroperoxides in living cells. Journal of the American Chemical Society [Internet]. 2010;(48):17065-17067. 访问链接
2009
Poor CB, Chen PR, Duguid E, Rice PA, He C. Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus. Journal of Biological Chemistry [Internet]. 2009;(35):23517-23524. 访问链接
Chen PR, Groff D, Guo J, Ou W, Cellitti S, Geierstanger BH, Schultz PG. A facile system for encoding unnatural amino acids in mammalian cells. Angewandte Chemie - International Edition [Internet]. 2009;(22):4052-4055. 访问链接
Chen PR, Nishida S, Poor CB, Cheng A, Bae T, Kuechenmeister L, Dunman PM, Missiakas D, He C. A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus. Molecular Microbiology [Internet]. 2009;(1):198-211. 访问链接
2008
Chen H, Hu J, Chen PR, Lan L, Li Z, Hicks LM, Dinner AR, He C. The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2008;(36):13586-13591. 访问链接
Chen PR, He C. Selective recognition of metal ions by metalloregulatory proteins. Current Opinion in Chemical Biology [Internet]. 2008;(2):214-221. 访问链接
2007
Wegner SV, Okesli A, Chen P, He C. Design of an emission ratiometric biosensor from MerR family proteins: A sensitive and selective sensor for Hg2+. Journal of the American Chemical Society [Internet]. 2007;(12):3474-3475. 访问链接
Sarkar SK, Andoy NM, Benítez JJ, Chen PR, Kong JS, He C, Chen P. Engineered holliday junctions as single-molecule reporters for protein-DNA interactions with application to a MerR-family regulator. Journal of the American Chemical Society [Internet]. 2007;(41):12461-12467. 访问链接
Chen PR, Wasinger EC, Zhao J, Lelie DVD, Chen LX, He C. Spectroscopic insights into lead(II) coordination by the selective lead(II)-binding protein PbrR691. Journal of the American Chemical Society [Internet]. 2007;(41):12350-12351. 访问链接
2006
Chen PR, Bae T, Williams WA, Duguid EM, Rice PA, Schneewind O, He C. An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. Nature Chemical Biology [Internet]. 2006;(11):591-595. 访问链接
2005
Chen P, Greenberg B, Taghavi S, Romano C, Lelie DVD, He C. An exceptionally selective lead(II)-regulatory protein from Ralstonia metallidurans: Development of a fluorescent lead(II) probe. Angewandte Chemie - International Edition [Internet]. 2005;(18):2715-2719. 访问链接

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