科研成果

2000
Liu Z-J, Jiang L, Li W-Z, Han Y-Z, Lai L-H. Conformational changes accompanying with the binding of protein and ligand. Acta Chimica Sinica. 2000;(7):772-776.
Wang R, Gao Y, Lai L. Calculating partition coefficient by atom-additive method. Perspectives in Drug Discovery and Design. 2000:47-66.
Wang H, Miao Z, Lai L, Xu X. An efficient procedure for cleavage of T-butyl protected cysteine in solid phase peptide synthesis. Synthetic Communications. 2000;(4):727-735.
Liang S, Xiao L, Mao F, Jiang L, Han Y, Lai L. Grafting of protein-protein binding sites. Chinese Science Bulletin. 2000;(18):1707-1712.
Mao F, Lai L. Molsee: A Tcl/Tk-based program to control Rasmol. Journal of Applied Crystallography. 2000;(6):1445-1446.
Cao W, Liu L, Klein DE, Wei L, Lai L. The monomer of the yeast transcriptional activator GCN4 recognizes its dimer binding DNA target sites without dimerization. Thermochimica Acta. 2000;(1):47-56.
Wang J, Lai L, Tang Y. Predictive toxicology of chemicals and database mining. Chinese Science Bulletin. 2000;(12):1093-1097.
Liu Z, Mao F, Li W, Han Y, Lai L. Calculation of protein surface loops using Monte-Carlo simulated annealing simulation. Journal of Molecular Modeling. 2000;(1):1-8.
Cao W, Liu L, Lai L, Tang Y. Molecular recognition: Monomer of the yeast transcriptional activator GCN4 recognizes its dimer DNA binding target sites specifically. Science in China, Series B: Chemistry. 2000;(5):466-476.
Liang S, Liu Z, Li W, Ni L, Lai L. Construction of protein binding sites in scaffold structures. Biopolymers [Internet]. 2000;(7):515-523. 访问链接
Lai L, Yokota H, Hung L-W, Kim R, Kim S-H. Crystal structure of archaeal RNase HII: A homologue of human major RNase H. Structure [Internet]. 2000;(8):897-904. 访问链接
Liang S, Li W, Xiao L, Wang J, Lai L. Grafting of protein-protein interaction epitope. Journal of Biomolecular Structure and Dynamics [Internet]. 2000;(5):821-828. 访问链接
Lai B, Cao A, Lai L. Organic cosolvents and hen egg white lysozyme folding. Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology [Internet]. 2000;(1):115-122. 访问链接
1999
Li W-Z, Wang R-X, Lin D-W, Mao F-L, Han Y-Z, Lai L-H. Progress of bioinformatics database services. Progress in Biochemistry and Biophysics. 1999;(1):25-26.
Li W, Liu Z, Liang S, Han Y, Lai L. Rational screenning in combinatorial peptide libraries of protein functional loop. Chinese Science Bulletin. 1999;(23):2150-2154.
Tao P, Wang R, Lai L. Calculation of Peptide's Partition Coefficients by Amino Acid Addition Model. Acta Physico - Chimica Sinica. 1999;(5):453-.
Sha Y, Li Y, Wang Q, Fan K, Liu D, Lai L, Tang Y. CD evidence of a peptide ongoing α/β/random transition in different solutions. Protein and Peptide Letters. 1999;(3):137-140.
Sha Y, Li Y, Wang Q, Fan K, Liu D, Lai L, Tang Y. De novo design and CD studies of model β-sheet peptides. Protein and Peptide Letters. 1999;(3):131-135.
Wang H, Lai L, Miao Z, Xu X. Design, synthesis and DNA-binding activities of GCN4 peptide dimer studied by circular dichroism spectroscopy. Protein and Peptide Letters. 1999;(4):245-252.
Liu H, Sha Y, Tan H, Yang H, Lai L. Bio-rational design of photosystem II inhibitors (VIII) - Molecular design, synthesis and inhibitory activity of acrylates (acrylamides). Science in China, Series B: Chemistry. 1999;(3):326-331.

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