科研成果 by Year: 2013

2013
Gu S, Yin N, Pei J, Lai L. Understanding traditional Chinese medicine anti-inflammatory herbal formulae by simulating their regulatory functions in the human arachidonic acid metabolic network. Molecular BioSystems [Internet]. 2013;(7):1931-1938. 访问链接
Qiu S, Lai L. Tailoring the pH dependence of human non-pancreatic secretory phospholipase A2 by engineering surface charges. Applied Biochemistry and Biotechnology [Internet]. 2013;(6):1454-1464. 访问链接
Gu S, Yin N, Pei J, Lai L. Understanding molecular mechanisms of traditional Chinese medicine for the treatment of influenza viruses infection by computational approaches. Molecular BioSystems [Internet]. 2013;(11):2696-2700. 访问链接
Zhang C, Shen Q, Tang B, Lai L. Computational design of helical peptides targeting TNFα. Angewandte Chemie - International Edition [Internet]. 2013;(42):11059-11062. 访问链接
Bi S, Yu D, Si G, Luo C, Li T, Ouyang Q, Jakovljevic V, Sourjik V, Tu Y, Lai L. Discovery of novel chemoeffectors and rational design of Escherichia coli chemoreceptor specificity. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2013;(42):16814-16819. 访问链接
Jin F, Yu C, Lai L, Liu Z. Ligand Clouds around Protein Clouds: A Scenario of Ligand Binding with Intrinsically Disordered Proteins. PLoS Computational Biology [Internet]. 2013;(10). 访问链接
Zhu C, Dai Z, Liang H, Zhang T, Gai F, Lai L. Slow and bimolecular folding of a de novo designed monomeric protein DS119. Biophysical Journal [Internet]. 2013;(9):2141-2148. 访问链接
Qiu S, Lai L. Antibacterial properties of recombinant human non-pancreatic secretory phospholipase A2. Biochemical and Biophysical Research Communications [Internet]. 2013;(2):453-456. 访问链接
Bai Y, Xue H, Wang K, Cai L, Qiu J, Bi S, Lai L, Cheng M, Liu S, Liu K. Covalent fusion inhibitors targeting HIV-1 gp41 deep pocket. Amino Acids [Internet]. 2013;(2):701-713. 访问链接
Yuan Y, Pei J, Lai L. Binding site detection and druggability prediction of protein targets for structure-based drug design. Current Pharmaceutical Design [Internet]. 2013;(12):2326-2333. 访问链接
Meng H, Liu Y, Zhai Y, Lai L. Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase. European Journal of Medicinal Chemistry [Internet]. 2013:160-167. 访问链接
Yin N, Pei J, Lai L. A comprehensive analysis of the influence of drug binding kinetics on drug action at molecular and systems levels. Molecular BioSystems [Internet]. 2013;(6):1381-1389. 访问链接
He S, Li C, Liu Y, Lai L. Discovery of highly potent microsomal prostaglandin E2 synthase 1 inhibitors using the active conformation structural model and virtual screen. Journal of Medicinal Chemistry [Internet]. 2013;(8):3296-3309. 访问链接