科研成果

2010
Qi Y, Huang Y, Liang H, Liu Z, Lai L. Folding simulations of a de Novo designed protein with a βαβ fold. Biophysical Journal [Internet]. 2010;(2):321-329. 访问链接
Li C, Qi Y, Teng X, Yang Z, Wei P, Zhang C, Tan L, Zhou L, Liu Y, Lai L. Maturation mechanism of severe acute respiratory syndrome (SARS) coronavirus 3C-like proteinase. Journal of Biological Chemistry [Internet]. 2010;(36):28134-28140. 访问链接
Jiang X, Zhou L, Wu Y, Wei D, Sun C, Jia J, Liu Y, Lai L. Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis. ChemBioChem [Internet]. 2010;(8):1120-1128. 访问链接
Gao X, Wang J, Yu D-Q, Bian F, Xie B-B, Chen X-L, Zhou B-C, Lai L-H, Wang Z-X, Wu J-W, et al. Structural basis for the autoprocessing of zinc metalloproteases in the thermolysin family. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2010;(41):17569-17574. 访问链接
2009
Wang Z, Cao A, Lai L. High activity of Mj HSP16.5 under acidic condition. Science in China, Series B: Chemistry. 2009;(3):325-331.
Liu Y, Chen Z, Shang E-C, Yang K, Wei D-G, Zhou L, Jiang X-L, He C, Lai L-H. Controlling arachidonic acid metabolic network: From single-to multi-target inhibitors of key enzymes. Yaoxue Xuebao [Internet]. 2009;(3):231-241. 访问链接
Liang H, Chen H, Fan K, Wei P, Guo X, Jin C, Zeng C, Tang C, Lai L. De novo design of a bab motif. Angewandte Chemie - International Edition [Internet]. 2009;(18):3301-3303. 访问链接
Ni S, Yuan Y, Huang J, Mao X, Lv M, Zhu J, Shen X, Pei J, Lai L, Jiang H, et al. Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. Journal of Medicinal Chemistry [Internet]. 2009;(17):5295-5298. 访问链接
Zhu X, Lai L. A novel method for enzyme design. Journal of Computational Chemistry [Internet]. 2009;(2):256-267. 访问链接
Hu J, Cui G, Li C, Liu C, Shang E, Lai L, Jin C, Wang J, Xia B. Structure and novel functional mechanism of Drosophila SNF in sex-lethal splicing. PLoS ONE [Internet]. 2009;(9). 访问链接
2008
Wang Z, Lai B, Cao J, Li Z, Qu L-L, Cao A-N, Lai L-H. Hierarchical unfolding of Mj HSP16.5. Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica. 2008;(10):1745-1750.
Jiang X, Zhou L, Wei D, Meng H, Liu Y, Lai L. Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorganic and Medicinal Chemistry Letters [Internet]. 2008;(24):6549-6552. 访问链接
Zhou L, Fang C, Wei P, Liu S, Liu Y, Lai L. Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives. Journal of Medicinal Chemistry [Internet]. 2008;(12):3360-3366. 访问链接
Wei D, Jiang X, Zhou L, Chen J, Chen Z, He C, Yang K, Liu Y, Pei J, Lai L. Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. Journal of Medicinal Chemistry [Internet]. 2008;(24):7882-7888. 访问链接
Yang K, Bai H, Ouyang Q, Lai L, Tang C. Finding multiple target optimal intervention in disease-related molecular network. Molecular Systems Biology [Internet]. 2008. 访问链接
Quan L, Wei D, Jiang X, Liu Y, Li Z, Li N, Li K, Liu F, Lai L. Resurveying the Tris buffer solution: The specific interaction between tris(hydroxymethyl)aminomethane and lysozyme. Analytical Biochemistry [Internet]. 2008;(2):144-150. 访问链接
Deng W, Cao A, Lai L. Distinguishing the cross-β spine arrangements in amyloid fibrils using FRET analysis. Protein Science [Internet]. 2008;(6):1102-1105. 访问链接
Bai H, Ma W, Liu S, Lai L. Dynamic property is a key determinant for protein-protein interactions. Proteins: Structure, Function and Genetics [Internet]. 2008;(4):1323-1331. 访问链接
Cao A, Wang Z, Wei P, Xu F, Cao J, Lai L. Preheating induced homogeneity of the small heat shock protein from Methanococcus jannaschii. Biochimica et Biophysica Acta - Proteins and Proteomics [Internet]. 2008;(3):489-495. 访问链接
Lu R-C, Cao A-N, Lai L-H, Xiao J-X. Protein-surfactant interaction: Differences between fluorinated and hydrogenated surfactants. Colloids and Surfaces B: Biointerfaces [Internet]. 2008;(1):98-103. 访问链接

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