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Genetic Susceptibility, Change in Physical Activity, and Long-term Weight Gain

Citation:

Wang T, Huang T, Heianza Y, Sun D, Zheng Y, Ma W, Jensen MK, Kang JH, Wiggs JL, Pasquale LR, et al. Genetic Susceptibility, Change in Physical Activity, and Long-term Weight Gain. DiabetesDiabetesDiabetes. 2017;66:2704-2712.

摘要:

Whether change in physical activity over time modifies the genetic susceptibility to long-term weight gain is unknown. We calculated a BMI-genetic risk score (GRS) based on 77 BMI-associated single nucleotide polymorphisms (SNPs) and a body fat percentage (BF%)-GRS based on 12 BF%-associated SNPs in 9,390 women from the Nurses' Health Study (NHS) and 5,291 men from the Health Professionals Follow-Up Study (HPFS). We analyzed the interactions between each GRS and change in physical activity on BMI/body weight change within five 4-year intervals from 1986 to 2006 using multivariable generalized linear models with repeated-measures analyses. Both the BMI-GRS and the BF%-GRS were associated with long-term increases in BMI/weight, and change in physical activity consistently interacted with the BF%-GRS on BMI change in the NHS (P for interaction = 0.025) and HPFS (P for interaction = 0.001). In the combined cohorts, 4-year BMI change per 10-risk allele increment was -0.02 kg/m(2) among participants with greatest increase in physical activity and 0.24 kg/m(2) among those with greatest decrease in physical activity (P for interaction < 0.001), corresponding to 0.01 kg versus 0.63 kg weight changes every 4 years (P for interaction = 0.001). Similar but marginal interactions were observed for the BMI-GRS (P for interaction = 0.045). Our data indicate that the genetic susceptibility to weight gain may be diminished by increasing physical activity.

附注:

Wang, TiangeHuang, TaoHeianza, YorikoSun, DianjianyiZheng, YanMa, WenjieJensen, Majken KKang, Jae HWiggs, Janey LPasquale, Louis RRimm, Eric BManson, JoAnn EHu, Frank BWillett, Walter CQi, LuR01 DK078616/DK/NIDDK NIH HHS/U01 HG004728/HG/NHGRI NIH HHS/P01 CA087969/CA/NCI NIH HHS/P01 CA055075/CA/NCI NIH HHS/U01 CA167552/CA/NCI NIH HHS/R01 DK091718/DK/NIDDK NIH HHS/R21 HL126024/HL/NHLBI NIH HHS/R01 HL034594/HL/NHLBI NIH HHS/UM1 CA186107/CA/NCI NIH HHS/R01 EY015473/EY/NEI NIH HHS/U01 DK078616/DK/NIDDK NIH HHS/R01 DK100383/DK/NIDDK NIH HHS/R01 HL071981/HL/NHLBI NIH HHS/UM1 CA167552/CA/NCI NIH HHS/R01 HL035464/HL/NHLBI NIH HHS/R01 CA049449/CA/NCI NIH HHS/U01 CA049449/CA/NCI NIH HHS/Diabetes. 2017 Oct;66(10):2704-2712. doi: 10.2337/db17-0071. Epub 2017 Jul 12.