<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">T. Wang</style></author><author><style face="normal" font="default" size="100%">Huang, T.</style></author><author><style face="normal" font="default" size="100%">Heianza, Y.</style></author><author><style face="normal" font="default" size="100%">Sun, D.</style></author><author><style face="normal" font="default" size="100%">Zheng, Y.</style></author><author><style face="normal" font="default" size="100%">W. Ma</style></author><author><style face="normal" font="default" size="100%">Jensen, M. K.</style></author><author><style face="normal" font="default" size="100%">Kang, J. H.</style></author><author><style face="normal" font="default" size="100%">Wiggs, J. L.</style></author><author><style face="normal" font="default" size="100%">Pasquale, L. R.</style></author><author><style face="normal" font="default" size="100%">Rimm, E. B.</style></author><author><style face="normal" font="default" size="100%">Manson, J. E.</style></author><author><style face="normal" font="default" size="100%">Hu, F. B.</style></author><author><style face="normal" font="default" size="100%">Willett, W. C.</style></author><author><style face="normal" font="default" size="100%">Qi, L.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Genetic Susceptibility, Change in Physical Activity, and Long-term Weight Gain</style></title><secondary-title><style face="normal" font="default" size="100%">DiabetesDiabetesDiabetes</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Diabetes</style></alt-title><short-title><style face="normal" font="default" size="100%">DiabetesDiabetes</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Weight</style></keyword><keyword><style  face="normal" font="default" size="100%">Exercise/*physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Prospective Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Weight Gain/genetics/physiology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">10</style></number><edition><style face="normal" font="default" size="100%">2017/07/14</style></edition><volume><style face="normal" font="default" size="100%">66</style></volume><pages><style face="normal" font="default" size="100%">2704-2712</style></pages><isbn><style face="normal" font="default" size="100%">1939-327X (Electronic)0012-1797 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Whether change in physical activity over time modifies the genetic susceptibility to long-term weight gain is unknown. We calculated a BMI-genetic risk score (GRS) based on 77 BMI-associated single nucleotide polymorphisms (SNPs) and a body fat percentage (BF%)-GRS based on 12 BF%-associated SNPs in 9,390 women from the Nurses&amp;#039; Health Study (NHS) and 5,291 men from the Health Professionals Follow-Up Study (HPFS). We analyzed the interactions between each GRS and change in physical activity on BMI/body weight change within five 4-year intervals from 1986 to 2006 using multivariable generalized linear models with repeated-measures analyses. Both the BMI-GRS and the BF%-GRS were associated with long-term increases in BMI/weight, and change in physical activity consistently interacted with the BF%-GRS on BMI change in the NHS (P for interaction = 0.025) and HPFS (P for interaction = 0.001). In the combined cohorts, 4-year BMI change per 10-risk allele increment was -0.02 kg/m(2) among participants with greatest increase in physical activity and 0.24 kg/m(2) among those with greatest decrease in physical activity (P for interaction &amp;lt; 0.001), corresponding to 0.01 kg versus 0.63 kg weight changes every 4 years (P for interaction = 0.001). Similar but marginal interactions were observed for the BMI-GRS (P for interaction = 0.045). Our data indicate that the genetic susceptibility to weight gain may be diminished by increasing physical activity.</style></abstract><work-type><style face="normal" font="default" size="100%">Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov&amp;#039;t</style></work-type><accession-num><style face="normal" font="default" size="100%">28701334</style></accession-num><notes><style face="normal" font="default" size="100%">Wang, TiangeHuang, TaoHeianza, YorikoSun, DianjianyiZheng, YanMa, WenjieJensen, Majken KKang, Jae HWiggs, Janey LPasquale, Louis RRimm, Eric BManson, JoAnn EHu, Frank BWillett, Walter CQi, LuR01 DK078616/DK/NIDDK NIH HHS/U01 HG004728/HG/NHGRI NIH HHS/P01 CA087969/CA/NCI NIH HHS/P01 CA055075/CA/NCI NIH HHS/U01 CA167552/CA/NCI NIH HHS/R01 DK091718/DK/NIDDK NIH HHS/R21 HL126024/HL/NHLBI NIH HHS/R01 HL034594/HL/NHLBI NIH HHS/UM1 CA186107/CA/NCI NIH HHS/R01 EY015473/EY/NEI NIH HHS/U01 DK078616/DK/NIDDK NIH HHS/R01 DK100383/DK/NIDDK NIH HHS/R01 HL071981/HL/NHLBI NIH HHS/UM1 CA167552/CA/NCI NIH HHS/R01 HL035464/HL/NHLBI NIH HHS/R01 CA049449/CA/NCI NIH HHS/U01 CA049449/CA/NCI NIH HHS/Diabetes. 2017 Oct;66(10):2704-2712. doi: 10.2337/db17-0071. Epub 2017 Jul 12.</style></notes><custom2><style face="normal" font="default" size="100%">5606317</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.Shanghai Institute of Endocrine and Metabolic Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Epidemiology Domain, Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women&amp;#039;s Hospital and Harvard Medical School, Boston, MA.Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.Division of Preventive Medicine, Department of Medicine, Brigham and Women&amp;#039;s Hospital and Harvard Medical School, Boston, MA.Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA lqi1@tulane.edu.</style></auth-address></record></records></xml>