@article {19888,
	title = {Genetic Susceptibility, Change in Physical Activity, and Long-term Weight Gain},
	journal = {DiabetesDiabetesDiabetes},
	volume = {66},
	number = {10},
	year = {2017},
	note = {Wang, TiangeHuang, TaoHeianza, YorikoSun, DianjianyiZheng, YanMa, WenjieJensen, Majken KKang, Jae HWiggs, Janey LPasquale, Louis RRimm, Eric BManson, JoAnn EHu, Frank BWillett, Walter CQi, LuR01 DK078616/DK/NIDDK NIH HHS/U01 HG004728/HG/NHGRI NIH HHS/P01 CA087969/CA/NCI NIH HHS/P01 CA055075/CA/NCI NIH HHS/U01 CA167552/CA/NCI NIH HHS/R01 DK091718/DK/NIDDK NIH HHS/R21 HL126024/HL/NHLBI NIH HHS/R01 HL034594/HL/NHLBI NIH HHS/UM1 CA186107/CA/NCI NIH HHS/R01 EY015473/EY/NEI NIH HHS/U01 DK078616/DK/NIDDK NIH HHS/R01 DK100383/DK/NIDDK NIH HHS/R01 HL071981/HL/NHLBI NIH HHS/UM1 CA167552/CA/NCI NIH HHS/R01 HL035464/HL/NHLBI NIH HHS/R01 CA049449/CA/NCI NIH HHS/U01 CA049449/CA/NCI NIH HHS/Diabetes. 2017 Oct;66(10):2704-2712. doi: 10.2337/db17-0071. Epub 2017 Jul 12.},
	month = {Oct},
	pages = {2704-2712},
	type = {Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov\&$\#$039;t},
	edition = {2017/07/14},
	abstract = {Whether change in physical activity over time modifies the genetic susceptibility to long-term weight gain is unknown. We calculated a BMI-genetic risk score (GRS) based on 77 BMI-associated single nucleotide polymorphisms (SNPs) and a body fat percentage (BF\%)-GRS based on 12 BF\%-associated SNPs in 9,390 women from the Nurses\&$\#$039; Health Study (NHS) and 5,291 men from the Health Professionals Follow-Up Study (HPFS). We analyzed the interactions between each GRS and change in physical activity on BMI/body weight change within five 4-year intervals from 1986 to 2006 using multivariable generalized linear models with repeated-measures analyses. Both the BMI-GRS and the BF\%-GRS were associated with long-term increases in BMI/weight, and change in physical activity consistently interacted with the BF\%-GRS on BMI change in the NHS (P for interaction = 0.025) and HPFS (P for interaction = 0.001). In the combined cohorts, 4-year BMI change per 10-risk allele increment was -0.02 kg/m(2) among participants with greatest increase in physical activity and 0.24 kg/m(2) among those with greatest decrease in physical activity (P for interaction \&lt; 0.001), corresponding to 0.01 kg versus 0.63 kg weight changes every 4 years (P for interaction = 0.001). Similar but marginal interactions were observed for the BMI-GRS (P for interaction = 0.045). Our data indicate that the genetic susceptibility to weight gain may be diminished by increasing physical activity.},
	keywords = {*Body Mass Index, Adult, Aged, Body Weight, Exercise/*physiology, Female, Genetic Predisposition to Disease/genetics, Humans, Male, Middle Aged, Prospective Studies, Weight Gain/genetics/physiology},
	isbn = {1939-327X (Electronic)0012-1797 (Linking)},
	author = {T. Wang and Huang, T. and Heianza, Y. and Sun, D. and Zheng, Y. and W. Ma and Jensen, M. K. and Kang, J. H. and Wiggs, J. L. and Pasquale, L. R. and Rimm, E. B. and Manson, J. E. and Hu, F. B. and Willett, W. C. and Qi, L.}
}
