科研成果

2005
Zheng M, Reynolds C, Jo S-H, Wersto R, Han Q, Xiao R-P. Intracellular acidosis-activated p38 MAPK signaling and its essential role in cardiomyocyte hypoxic injury. FASEB Journal [Internet]. 2005;(1):109-111. 访问链接
2004
Zheng M, Hou R, Han Q, Xiao R-P. Different regulation of ERK1/2 activation by β-adrenergic receptor subtypes in adult mouse cardiomyocytes. Heart Lung and Circulation [Internet]. 2004;(2):179-183. 访问链接
Beigi F, Chakir K, Xiao R-P, Wainer IW. G-protein-coupled receptor chromatographic stationary phases. 2. Ligand-induced conformational mobility in an immobilized β2- adrenergic receptor. Analytical Chemistry [Internet]. 2004;(24):7187-7193. 访问链接 SCI被引用次数:40.
Leblais V, Jo S-H, Chakir K, Maltsev V, Zheng M, Crow MT, Wang W, Lakatta EG, Xiao R-P. Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes. Circulation Research [Internet]. 2004;(12):1183-1190. 访问链接 SCI被引用次数:43.
Zheng M, Hou R, Xiao R-P. Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility. Acta Pharmacologica Sinica [Internet]. 2004;(10):1299-1305. 访问链接
Pepe S, Brink OVDWV, Lakatta EG, Xiao R-P. Cross-talk of opioid peptide receptor and β-adrenergic receptor signalling in the heart. Cardiovascular Research [Internet]. 2004;(3):414-422. 访问链接 SCI被引用次数:57.
Ding J-H, Xu X, Yang D, Chu P-H, Dalton ND, Ye Z, Yeakley JM, Cheng H, Xiao R-P, Jr. JR, et al. Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO Journal [Internet]. 2004;(4):885-896. 访问链接 SCI被引用次数:96.
Zheng M, Han Q-D, Xiao R-P. Distinct beta-adrenergic receptor subtype signaling in the heart and their pathophysiological relevance. Sheng li xue bao [Acta physiologica Sinica] [Internet]. 2004;(1):1-15. 访问链接
Chen K-H, Guo X, Ma D, Guo Y, Li Q, Yang D, Li P, Qiu X, Wen S, Xiao R-P, et al. Dysregulation of HSG triggers vascular proliferative disorders. Nature Cell Biology [Internet]. 2004;(9):872-883. 访问链接 SCI被引用次数:236.
Xiao R-P, Balke CW. Na+/Ca2+ exchange linking β2- adrenergic Gi signaling to heart failure: Associated defect of adrenergic contractile support. Journal of Molecular and Cellular Cardiology [Internet]. 2004;(1):7-11. 访问链接 SCI被引用次数:12.
Patterson AJ, Zhu W, Chow A, Agrawal R, Kosek J, Xiao R, Kobilka B. Protecting the myocardium: A role for the β2 adrenergic receptor in the heart. Critical Care Medicine [Internet]. 2004;(4):1041-1048. 访问链接 SCI被引用次数:68.
Xiao R-P, Zhu W, Zheng M, Chakir K, Bond R, Lakatta EG, Cheng H. Subtype-specific β-adrenoceptor signaling pathways in the heart and their potential clinical implications. Trends in Pharmacological Sciences [Internet]. 2004;(7):358-365. 访问链接
Wang W, Zhu W, Wang S, Yang D, Crow MT, Xiao R-P, Cheng H. Sustained β1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circulation Research [Internet]. 2004;(8):798-806. 访问链接 SCI被引用次数:142.
Chu G, Egnaczyk GF, Zhao W, Jo S-H, Fan G-C, Maggio JE, Xiao R-P, Kranias EG. Phosphoproteome Analysis of Cardiomyocytes Subjected to β-Adrenergic Stimulation: Identification and Characterization of a Cardiac Heat Shock Protein p20. Circulation Research [Internet]. 2004;(2):184-193. 访问链接 SCI被引用次数:55.
2003
Aiwu C, Shuqin W, Dongmei Y, Ruiping X, Mattson MP. Calmodulin mediates brain-derived neurotrophic factor cell survival signaling upstream of Akt kinase in embryonic neocortical neurons. Journal of Biological Chemistry [Internet]. 2003;(9):7591-7599. 访问链接 SCI被引用次数:76.
Yang D, Song L-S, Zhu W-Z, Chakir K, Wang W, Wu C, Wang Y, Xiao R-P, Chen WSR, Cheng H. Calmodulin regulation of excitation-contraction coupling in cardiac myocytes. Circulation Research [Internet]. 2003;(6):659-667. 访问链接 SCI被引用次数:18.
Xiao R-P, Zhang S-J, Chakir K, Avdonin P, Zhu W, Bond RA, Balke WC, Lakatta EG, Cheng H. Enhanced Gi signaling selectively negates β 2-adrenergic receptor (AR)- but not β1-AR-mediated positive inotropic effect in myocytes from failing rat hearts. Circulation [Internet]. 2003;(13):1633-1639. 访问链接 SCI被引用次数:99.
Zhu W-Z, Wang S-Q, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kobilka BK, Cheng H, Xiao R-P. Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. Journal of Clinical Investigation [Internet]. 2003;(5):617-625. 访问链接
Sasaki N, Murata M, Guo Y, Jo S-H, Ohler A, Akao M, O'Rourke B, Xiao R-P, Bolli R, Marbán E. MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning. Circulation [Internet]. 2003;(8):1183-1188. 访问链接 SCI被引用次数:30.
Chakir K, Xiang Y, Yang D, Zhang S-J, Cheng H, Kobilka BK, Xiao R-P. The Third Intracellular Loop and the Carboxyl Terminus of β 2-Adrenergic Receptor Confer Spontaneous Activity of the Receptor. Molecular Pharmacology [Internet]. 2003;(5):1048-1058. 访问链接 SCI被引用次数:21.

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