科研成果

2009
Chakir K, Daya SK, Aiba T, Tunin RS, Dimaano VL, Abraham TP, Jacques K, Lai EW, Pacak K, Zhu W-Z, et al. Mechanisms of enhanced β-adrenergic reserve from cardiac resynchronization therapy. Circulation [Internet]. 2009;(9):1231-1240. 访问链接 SCI被引用次数:75.
Woo AY-H, Wang T-B, Zeng X, Zhu W, Abernethy DR, Wainer IW, Xiao R-P. Stereochemistry of an agonist determines coupling preference of β 2-adrenoceptor to different g proteins in cardiomyocytes. Molecular Pharmacology [Internet]. 2009;(1):158-165. 访问链接 SCI被引用次数:66.
2008
Ahmet I, Krawczyk M, Zhu W, Woo AY-H, Morrell C, Poosala S, Xiao R-P, Lakatta EG, Talan MI. Cardioprotective and survival benefits of long-term combined therapy with β2 adrenoreceptor (AR) agonist and β1 AR blocker in dilated cardiomyopathy postmyocardial infarction. Journal of Pharmacology and Experimental Therapeutics [Internet]. 2008;(2):491-499. 访问链接 SCI被引用次数:46.
Luo D, Yang D, Lan X, Li K, Li X, Chen J, Zhang Y, Xiao R-P, Han Q, Cheng H. Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes. Cell Calcium [Internet]. 2008;(2):165-174. 访问链接 SCI被引用次数:67.
2007
Zhu W, Woo AY-H, Yang D, Cheng H, Crow MT, Xiao R-P. Activation of CaMKIIδC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis. Journal of Biological Chemistry [Internet]. 2007;(14):10833-10839. 访问链接 SCI被引用次数:84.
Yang D, Zhu W-Z, Xiao B, Brochet DXP, Chen WSR, Lakatta EG, Xiao R-P, Cheng H. Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. Circulation Research [Internet]. 2007;(3):399-407. 访问链接 SCI被引用次数:66.
Jozwiak K, Khalid C, Tanga MJ, Berzetei-Gurske I, Jimenez L, Kozocas JA, Woo A, Zhu W, Xiao R-P, Abernethy DR, et al. Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the β2 adrenergic receptor. Journal of Medicinal Chemistry [Internet]. 2007;(12):2903-2915. 访问链接 SCI被引用次数:51.
Guo X, Chen K-H, Guo Y, Liao H, Tang J, Xiao R-P. Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway. Circulation Research [Internet]. 2007;(11):1113-1122. 访问链接 SCI被引用次数:116.
Shen T, Zheng M, Cao C, Chen C, Tang J, Zhang W, Cheng H, Chen K-H, Xiao R-P. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. Journal of Biological Chemistry [Internet]. 2007;(32):23354-23361. 访问链接 SCI被引用次数:103.
2006
Yang Y, Zhu W-Z, Joiner M-L, Zhang R, Oddis CV, Hou Y, Yang J, Price EE, Gleaves L, Eren M, et al. Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 2006;(6):H3065-H3075. 访问链接
Beigi F, Bertucci C, Zhu W, Chakir K, Wainer IW, Xiao R-P, Abernethy DR. Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol. Chirality [Internet]. 2006;(10):822-827. 访问链接 SCI被引用次数:22.
Luo D-L, Gao J, Lan X-M, Wang G, Wei S, Xiao R-P, Han Q-D. Role of inositol 1,4,5-trisphosphate receptors in α1- adrenergic receptor-induced cardiomyocyte hypertrophy. Acta Pharmacologica Sinica [Internet]. 2006;(7):895-900. 访问链接 SCI被引用次数:13.
Xiao R-P, Zhu W, Zheng M, Cao C, Zhang Y, Lakatta EG, Han Q. Subtype-specific α1- and β-adrenoceptor signaling in the heart. Trends in Pharmacological Sciences [Internet]. 2006;(6):330-337. 访问链接 SCI被引用次数:114.
Vinogradova TM, Lyashkov AE, Zhu W, Ruknudin AM, Sirenko S, Yang D, Deo S, Barlow M, Johnson S, Caffrey JL, et al. High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circulation Research [Internet]. 2006;(4):505-514. 访问链接 SCI被引用次数:179.
2005
Xu X, Yang D, Ding J-H, Wang W, Chu P-H, Dalton ND, Wang H-Y, Jr. JBR, Ye Z, Liu F, et al. ASF/SF2-regulated CaMKIIδ alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell [Internet]. 2005;(1):59-72. 访问链接 SCI被引用次数:213.
Luo D, Sun H, Xiao R, Han Q. Caffeine induced Ca2+ release and capacitative Ca2+ entry in human embryonic kidney (HEK293) cells. European Journal of Pharmacology [Internet]. 2005;(2-3):109-115. 访问链接 SCI被引用次数:17.
Luo D, Sun H, Lan X, Xiao R, Han Q. Direct coupling between arachidonic acid-induced Ca2+ release and Ca2+ entry in HEK293 cells. Prostaglandins and Other Lipid Mediators [Internet]. 2005;(1-4):141-151. 访问链接 SCI被引用次数:7.
Zheng M, Zhu W, Han Q, Xiao R-P. Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling. Pharmacology and Therapeutics [Internet]. 2005;(3):257-268. 访问链接 SCI被引用次数:75.
Zhu W, Zeng X, Zheng M, Xiao R-P. The enigma of β2-adrenergic receptor Gi signaling in the heart: The good, the bad, and the ugly. Circulation Research [Internet]. 2005;(6):507-509. 访问链接 SCI被引用次数:49.
Zhu W-Z, Chakir K, Zhang S, Yang D, Lavoie C, Bouvier M, Hébert TE, Lakatta EG, Cheng H, Xiao R-P. Heterodimerization of β1- and β2-adrenergic receptor subtypes optimizes β-adrenergic modulation of cardiac contractility. Circulation Research [Internet]. 2005;(3):244-251. 访问链接 SCI被引用次数:82.

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