科研成果 by Year: 2009

2009
Da CS, Wang JR, Yin XG, Fan XY, Liu Y, Yu SL. Highly Catalytic Asymmetric Addition of Deactivated Alkyl Grignard Reagents to Aldehydes. Organic LettersOrganic LettersOrganic Letters. 2009;11:5578-5581.Abstract
Generally used and highly reactive RMgBr reagents were effectively deactivated by bis[2-(N,N-dimethylamino)ethyl] ether and then were employed in the highly enantioselective addition of Grignard reagents to aldehydes. The reaction was catalyzed by the complex of commercially available (S)-BINOL and Ti(O'Pr-)(4) under mild conditions. Compared with the other observed Grignard reagents, alkyl Grignard reagents showed higher enantioselectivity and they achieved >99% ee.
Zhang D, Jiang W, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Research [Internet]. 2009;(4):429-438. 访问链接
Wang J-T, Chen C, Wang EG, Wang D-S, Mizuseki H, Kawazoe Y. Highly stable and symmetric boron caged B@ Co12 @ B80 core-shell cluster. Applied Physics Letters. 2009;(13). SCI被引用次数：9.
Luo C, Jiang L, Liang S, Ouyang Q, Ji H, Chen Y. High-throughput microfluidic system for monitoring diffusion-based monolayer yeast cell culture over long time periods. Biomedical Microdevices [Internet]. 2009;(5):981-986. 访问链接 SCI被引用次数：15.
Wan D, Xu J, Zhang J, Tong X, Hu J. Historical and projected emissions of major halocarbons in China. Atmospheric EnvironmentAtmospheric Environment. 2009;43:5822-5829.
Gao G, Li J-T, Kong L, Tao L, Wei L. Human herpesvirus miRNAs statistically preferentially target host genes involved in cell signaling and adhesion junction pathways. Cell Research [Internet]. 2009;(5):665-667. 访问链接 SCI被引用次数：8.
Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Santo JDP, et al. Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook. Cell Host and Microbe [Internet]. 2009;(1):5-9. 访问链接 SCI被引用次数：164.
Chen J, Li Z, Yue S, Gong Q. Hybrid long-range surface plasmon-polariton modes with tight field confinement guided by asymmetrical waveguides. OPTICS EXPRESS. 2009;17:23603-23609.Abstract SCI被引用次数：45.
A finite width dielectric-metal-dielectric (DMD) waveguide placed on a substrate is numerically investigated near the telecom wavelength lambda = 1550 nm by the finite element method. With proper waveguide sizes, the asymmetrical DMD waveguide can support hybrid long-range surface plasmon-polariton modes which have tight field confinement (similar to 700 nm) and long propagation lengths (L> 300 mu m) simultaneously. Compact plasmonic waveguide-ring resonators (WRRs) based on such asymmetrical DMD waveguide show high quality factors compared with dielectric-loaded surface plasmon-polariton, channel plasmon polariton, plasmonic whispering-gallery microcavity, and pure dielectric waveguide cases. (C) 2009 Optical Society of America
Qiu X, Bigsby RM, Hites RA. Hydroxylated Metabolites of Polybrominated Diphenyl Ethers in Human Blood Samples from the United States. Environmental Health Perspectives. 2009;117:93-98.Abstract
BACKGROUND: A previous study from our laboratory showed that polybrominated diphenyl ethers (PBDEs) were metabolized to hydroxylated PBDEs (HO-PBDEs) in mice and that para-HO-PBDEs were the most abundant and, potentially, the most toxic metabolites. OBJECTIVE: The goal of this study was to determine the concentrations of HO-PBDEs in blood from pregnant women, who had not been intentionally or occupationally exposed to these flame retardants, and from their newborn babies. METHODS: Twenty human blood samples were obtained from a hospital in Indianapolis, Indiana, and analyzed for both PBDEs and HO-PBDEs using electron-capture negative-ionization gas chromatographic mass spectrometry. RESULTS: The metabolite pattern of HO-PBDEs in human blood was quite different from that found in mice; 5-HO-BDE-47 and 6-HO-BDE-47 were the most abundant metabolites of BDE-47, and 5'-HO-BDE-99 and 6'-HO-BDE-99 were the most abundant metabolites of BDE-99. The relative concentrations between precursor and corresponding metabolites indicated that BDE-99 was more likely to be metabolized than BDE-47 and BDE-100. In addition, three bromophenols were also detected as products of the cleavage of the diphenyl ether bond. The ratio of total hydroxylated metabolites relative to their PBDE precursors ranged from 0.10 to 2.8, indicating that hydroxylated metabolites of PBDEs were accumulated in human blood. CONCLUSIONS: The quite different PBDE metabolite pattern observed in humans versus mice indicates that different enzymes might be involved in the metabolic process. Although the levels of HO-PBDE metabolites found in human blood were low, these metabolites seemed to be accumulating.
Song Q, An X, Li D, Sodha NR, Boodhwani M, Tian Y, Sellke FW, Li J. Hyperglycemia attenuates angiogenic capability of survivin in endothelial cells. Microvascular Research [Internet]. 2009;(3):257-264. 访问链接 SCI被引用次数：16.
Xue Y, Petrovic N, Cao R, Larsson O, Lim S, Chen S, Feldmann HM, Liang Z, Zhu Z, Nedergaard J, et al. Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation. Cell Metabolism [Internet]. 2009;(1):99-109. 访问链接 SCI被引用次数：227.
Zhang C, Song QH, Li J, Tian Y. Hypoxia-induced expression of RTEF-1 (related transcriptional enhancer factor-1) in endothelial cells is independent of HIF-1 (hypoxia-inducible factor-1). Biochemical and Biophysical Research Communications [Internet]. 2009;(3):333-338. 访问链接 SCI被引用次数：4.
Messmer-Blust A, An X, Li J. Hypoxia-regulated angiogenic inhibitors. Trends in Cardiovascular Medicine [Internet]. 2009;(8):252-256. 访问链接 SCI被引用次数：24.
Kong Y, Nan K, Yin Y. Identification and characterization of CAC1 as a novel CDK2-associated cullin. Cell cycle (Georgetown, Tex.) [Internet]. 2009;(21):3544-3553. 访问链接 SCI被引用次数：24.
Ying K, Kejun N, Yuxin Y. Identification and characterization of CAC1 as a novel CDK2-associated cullin. Cell Cycle. 2009;(21):3552-3561.
Liu J, Wang H, Zhang H, Wu X, Zhang H, Deng Y, Yang Z, Lei A. Identification of a highly efficient alkylated pincer thioimido- palladium(II) complex as the active catalyst in negishi coupling. Chemistry - A European Journal [Internet]. 2009;(17):4437-4445. 访问链接 SCI被引用次数：35.
Wu Y, Zhang X, Yu J, Ouyang Q. Identification of a topological characteristic responsible for the biological robustness of regulatory networks. PLoS Computational Biology [Internet]. 2009;(7). 访问链接 SCI被引用次数：27.
Modamio V, Jungclaus A, Podolyak Z, Shi Y, Xu FR, Algora A, Bazzacco D, Escrig D, Fraile LM, Lenzi S, et al. Identification of yrast high-$K$ intrinsic states in $^188\mathrmOs$. Phys. Rev. C [Internet]. 2009;79:024310. 访问链接 SCI被引用次数：13.
Xiang J, Yang H, Che C, Zou H, Yang H, Wei Y, Quan J, Zhang H, Yang Z, Lin S. Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays. PLoS ONE. 2009;(2). SCI被引用次数：23.
Cao G, Liang L, Ma S, Zhao D. Image Quality Assessment Using Spatial Frequency Component, in Advances in Multimedia Information Processing - PCM 2009, 10th Pacific Rim Conference on Multimedia, Bangkok, Thailand, December 15-18, 2009 Proceedings.; 2009:201–211. 访问链接

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