The proliferation and spread of antibiotic-resistant bacteria (ARB) significantly threaten human health and ecosystem. Periodate (PI) based advanced oxidation process has potentials for water purification but limited by complex activators or activation process. Herein, we demonstrated that H2O2 could be used to activate PI, achieving efficient ARB disinfection performance. Particularly, we found that the PI/H2O2 system (0.1 mM for both oxidants) could inactivate ARB (Escherichia coli) within 35 min. The intracellular defense system attacked by HO· radicals generated in the disinfection system, resulting in the inactivation of ARB. Antibiotic resistance genes (ARGs) released with the lysis of cell membrane could be further degraded by HO· radicals. Moreover, we found that the PI/H2O2 system was effective to inactivate ARB in a broad range of ionic strengths, with coexisting common ions and humic acid, as well as in four typical actual water bodies. The PI/H2O2 system could also efficiently disinfect other types of bacteria and degrade typical organic contaminants. In addition, under sunlight irradiation, the ARB inactivation performance of the PI/H2O2 system could be greatly improved. This study provided a practical and efficient way for decontaminating ARB/ARGs-polluted water.
Coastal sediment cores provide important records of land-based antibiotics' deposition. This study examined sediment cores from the Hangzhou Bay, East China Sea, dating back to 1980–2020 using 210Pbex. The 40-year analysis revealed a mismatch between sediment depth and age. Wastewater treatment facilities have significantly reduced antibiotics discharge into the sea. We identified 27 antibiotics, with enrofloxacin (ERFX) and nadifloxacin (NDFX) exhibiting the highest average concentrations of 84.9 and 83.4 ng/g, respectively. Quinolones (QNs) were prominent, displaying strong co-occurrence and similar distribution patterns shaped by comparable soil-water distribution coefficient (Kd). QNs correlated positively with total antibiotic concentration, serving as indicators. We proposed a multi-dimensional risk assessment of antibiotics, encompassing ecological and antimicrobial resistance (AMR) risks, complementing each other. The assessment revealed antibiotics with distinct risks: sulfacetamide (SCM) and clindamycin (CLIN) exhibited high ecological risks, while ERFX, ciprofloxacin (CFX), norfloxacin (NFX), gatifloxacin (GTFX), moxifloxacin (MXFX), and marbofloxacin (MBFX) presented high AMR risks.
Chen W, Zhang Z, Zhang X, Shen Q, Yarom Y, Genkin D, Yan C, Wang Z. HyperHammer: Breaking Free from KVM-Enforced Isolation, in Proceedings of the 30th ACM International Conference on Architectural Support for Programming Languages and Operating Systems, Volume 2, ASPLOS 2025, Rotterdam, Netherlands, 30 March 2025 - 3 April 2025. ACM; 2025:545–559. 访问链接