摘要:

China has become one of the major recycling sites for the electronic waste (e-waste) from worldwide. Pollutants emerged from the e-waste dismantling and the subsequent health effects to populations are of great concern. Typically, exposure to organic pollutants, such as bisphenol A (BPA) especially generated from primitive dismantling, is an important scientific issue for their adverse health effects to local residents. In this study, 29 e-waste dismantling workers and 24 local residents from a dismantling area in North China were recruited as the exposure group. Residents (N = 53) living 40 km away from this e-waste area were selected as the reference. The median concentration of urinary BPA of the exposure group was 10.7 mu g.g(-1) creatinine, which was significantly higher than that of the references (0.66 mu g.g(-1) creatinine; P < 0.01), indicating that working and/or living in the e-waste area caused the elevated body burden of BPA. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) of the exposure group (median: 236 mu g.g(-1) creatinine) was higher than that of the references (median: 142 mu g.g(-1) creatinine) with a marginal significance (P = 0.055). Meanwhile, serum levels of glutathione S-transferase (GSH-ST) and Cu/Zn-Superoxide dismutase (Cu/Zn-SOD) were significantly lower in the exposure group, while glutathione peroxidase (GSHPx) was higher when compared to the references (P < 0.01). Significantly positive association between urinary BPA and 8-OHdG was found (P < 0.05); however, significantly negative association was found between BPA and serum GSH-ST (P < 0.01). After controlling for confounders, 34.9% (95% CI: 19.4%-52.3%) increment of urinary 8-OHdG and 5.46% (95% CI: 1.17%-9.56%) decrement of serum GSH-ST per one-fold increase of BPA were estimated. Those results provided evidence on high exposure level of BPA among the populations from the e-waste dismantling area and a high risk of oxidative damage to DNA.

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