科研成果 by Year: 2014

2014
Liu Y, Zhang J, Zhang X, Xie S. Depth-related changes of sediment ammonia-oxidizing microorganisms in a high-altitude freshwater wetland. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2014;98:5697-5707.Abstract SCI被引用次数：44.
Both ammonia-oxidizing bacteria (AOB) and archaea (AOA) might be the key microorganisms in ammonia conversion in ecosystems. However, the depth-related change of AOA and AOB in sediment ecosystem is still not clear. The relative contribution of AOA and AOB to nitrification in wetland sediment remains also unclear. Moreover, information about ammonia-oxidizing microorganisms in high-altitude freshwater wetland is still lacking. The present study investigated the relative abundances and community structures of AOA and AOB in sediments of a high-altitude freshwater wetland in Yunnan Province (China). Variations of the relative abundances and community structures of AOA and AOB were found in the wetland sediments, dependent on both sampling site and sediment depth. The relative abundances of AOA and AOB (0.04-3.84 and 0.01-0.52 %) and the AOA/AOB ratio (0.12-4.65) showed different depth-related change patterns. AOB community size was usually larger than AOA community size. AOB diversity was usually higher than AOA diversity. AOA diversity decreased with the increase of sediment depth, while AOB diversity showed no obvious link with the sediment depth. Pearson's correlation analysis showed that AOA diversity had a positive significant correlation with available phosphorus. Nitrosospira-like sequences, with different compositions, predominated in the wetland sediment AOB communities. This work could provide some new insights toward nitrification in freshwater sediment ecosystems.
Han M, Yuan Q, Sun X, Zhang H. Design and fabrication of integrated magnetic MEMS energy harvester for low frequency applications. Journal of Microelectromechanical Systems. 2014;23(1):204-212.
Jiang X, Ouyang Q, Luo C. Design of multi-well based single cell observation chip and its application on bacteria antibiotic property study. Beijing Daxue Xuebao (Ziran Kexue Ban)/Acta Scientiarum Naturalium Universitatis Pekinensis. 2014;(3):439-444.
Dalsgaard B, Carstensen DW, Fjeldså J, Maruyama PK, Rahbek C, Sandel B, Sonne J, Svenning J-C, Wang Z, Sutherland WJ. Determinants of bird species richness, endemism, and island network roles in Wallacea and the West Indies: is geography sufficient or does current and historical climate matter?. Ecology and Evolution. 2014;4:4019-4031.
Shang E, Liu Y, Wu Y, Zhu W, He C, Lai L. Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors. Bioorganic and Medicinal Chemistry. 2014;(8):2396-2402. SCI被引用次数：9.
Qu Z-W, Zhang Z-C, Fan J-J, Zhang R, Liu P-K. Development of a C-band 2.5-MW-peak-power broadband klystron based on high efficiency. IEEE Transactions on Plasma Science. 2014;42(1):79-83.
Lu Y, Yang K, Zhou K, Zhang Q, Pang B, Ren Q. Development of a SiPM-based PET imaging system for small animals. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2014;743:30–38.
Zhang Y, Ding J, Shen G, Zhong J, Wang C, Wei S, Chen C, Chen Y, Lu Y, Shen H, et al. Dietary and inhalation exposure to polycyclic aromatic hydrocarbons and urinary excretion of monohydroxy metabolites - A controlled case study in Beijing, China. Environmental Pollution [Internet]. 2014;184:515-522. 访问链接
Dai Z, Lai L. Differential simulated annealing: A robust and efficient global optimization algorithm for parameter estimation of biological networks. Molecular BioSystems. 2014;(6):1385-1392. SCI被引用次数：7.
Wang C, Tao L. Dimensional reduction of a V1 ring model with simple and complex cells. Journal of Computational Neuroscience. 2014. SCI被引用次数：0.
Sachs R, Lin Z, Odenthal P, Kawakami R, Shi J. Direct comparison of graphene devices before and after transfer to different substrates. Applied Physics Letters. 2014;(3). SCI被引用次数：8.
Zhang C, Tang B, Wang Q, Lai L. Discovery of binding proteins for a protein target using protein-protein docking-based virtual screening. Proteins: Structure, Function and Bioinformatics. 2014.
Shen Q, Chen J, Wang Q, Deng X, Liu Y, Lai L. Discovery of highly potent TNFα inhibitors using virtual screen. European Journal of Medicinal Chemistry. 2014:119-126. SCI被引用次数：13.
Wang Q, Qi Y, Yin N, Lai L. Discovery of novel allosteric effectors based on the predicted allosteric sites for Escherichia coli D-3-phosphoglycerate dehydrogenase. PLoS ONE. 2014;(4). SCI被引用次数：165.
Qiu S, Chen F, Liu Y, Lai L. Discovery of novel secretory phospholipase A2 inhibitors using virtual screen. Chemical Biology and Drug Design. 2014;(2):216-222. SCI被引用次数：3.
He X, Jing Y, Li K, Zhao Y, Yang C, Yang Q, Qiu X, Li G. DNA damage repair genes expression in population exposed to persistent organic pollutants. Journal of Environment and Health. 2014;31:1-5.Abstract
Objective To explore the relationship between persistent organic pollutants exposure and DNA damage repair in the residents in electronic waste disposing area (e-waste area). Methods Peripheral blood persistent organic pollutants contents of the residents (n=23) in e-waste area and control area(n=25) were determined in a region of north China. The expression of 126 genes of DNA damage repair pathway in the blood samples of two groups was determined by RNA-seq in November, 2011. Results Various POPs showed significantly higher concentration in the exposed group than those in non-exposed group. A total of 17 genes showed differential expression,four (NEIL3, EXO1,MA PK12 and TP73) of which showed significant differential expression between the two groups. A total of nine genes were up-regulated and eight genes were down -regulated among 17 differential expression genes. Interestingly,the expression of certain genes,i.e., MA PK12, EXO1, NTHL1, GADD45G, RA D51, RAD51B appeared to be more significantly different merely among the females of the exposed and non-exposed group,while the expression of RA D54L, DMC1, BBC3, UNG, XRCC6BP1, TP73 merely occurred differential among the males. Conclusion POPs contents in peripheral blood of residents in e -waste area increased significantly, DNA damage repair -related genes expression condition has changed. The differential expression of genes in DNA damage repair system participates in various DNA damage repair pathway and has an effect on it. Gender difference may exist in response to POPs-mediated DNA damage.目的了解电子垃圾处理区域人群中持久性有机污染物(POPs)暴露与DNA损伤修复的关系。方法于2011年11月,检测某电子垃圾处理区域居民(暴露组 ,n=23)及非暴露地区居民(非暴露组,n=25)外周血POPs含量。以RNA测序比较两组血样中DNA损伤修复通路中126个基因的表达情况。结果 暴露组人群外周血多氯联苯(PCBs)、多溴联苯醚(BDEs)、得克隆(DP)的含量高于非暴露组;17个基因出现差异表达,其中NEIL3、EXO1 、MAPK12、TP73表达出现统计学差异。17个差异表达基因中9个基因下调,8个基因上调。MAPK12、EXO1、NTHL1、GADD45G、 RAD51、RAD51B仅在女性暴露组和非暴露组间出现差异;而RAD54L、DMC1、BBC3、UNG、XRCC6BP1、TP73仅在男性出现差 异表达。结论本次调查的电子垃圾处理区域人群外周血POPs含量高于非暴露组,DNA损伤修复相关基因表达量存在一定差异。机体对POPs所致DNA损伤 的应答机制可能存在性别差异。
Wang J, Huang J, Zhang L, Huang Q. Do incentives still matter for the reform of irrigation management in the Yellow River Basin in China?. Journal of Hydrology. 2014;517:584–594.
Chen X, Yi H, Zhang L, Mo D, Chu J, Rozelle S. Do Poor Students benefit from China's Merge Program? Transfer Path and Educational Performance. Asia Pacific Journal of Education. 2014;34:15-35.
Gao Z, Qu B, Wu H, Gao C, Yang H, Zhang L, Xiao L, Chen Z, Gong Q. Donor Copolymer with Benzo[ 1,2-b: 4,5-b0] dithiophene and Quinoxaline Derivative Segments for Photovoltaic Applications. JOURNAL OF APPLIED POLYMER SCIENCE. 2014;131.Abstract SCI被引用次数：4.
A donor copolymer Poly\2,6-4,8-bis(2-ethylhexyl)benzo[1,2-b:3,4-b]dithiophene-5,8-2,3-b is(5-octylthiophen-2-yl)quinoxaline\ (PBDTThQx) with benzo[1,2-b:4,5-b]dithiophene and quinoxaline derivatives was synthesized and characterized with NMR, ultraviolet-visible spectroscopy, thermogravimetric analyses, and cyclic voltammetry. Photovoltaic devices with the configuration indium tin oxide-poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate)-PBDTThQx-[6,6]-phenyl-C-61-butyric acid methyl ester (PC61BM)-LiF-Al were fabricated, in which PBDTThQx performed as the electron donor and PC61BM was the electron acceptor in the active layer. The device presented reasonable photovoltaic properties when the weight ratio of PBDTThQx:PC61BM reached 1:3. The open-circuit voltage, fill factor, and power conversion efficiency were gauged to be 0.75 V, 0.59, and 0.74%, respectively. The experimental data implied that PBDTThQx would be a promising donor candidate in the application of polymer solar cells. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40279.
Gao Z, Qu B, Wu H, Gao C, Yang H, Zhang L, Xiao L, Chen Z, Gong Q. Donor Copolymer with Benzo[ 1,2-b: 4,5-b0] dithiophene and Quinoxaline Derivative Segments for Photovoltaic Applications. JOURNAL OF APPLIED POLYMER SCIENCE. 2014;131.

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