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Macronutrient-specific effect of the MTNR1B genotype on lipid levels in response to 2 year weight-loss diets

Citation:

Goni L, Sun D, Heianza Y, Wang T, Huang T, Cuervo M, Martinez JA, Shang X, Bray GA, Sacks FM, et al. Macronutrient-specific effect of the MTNR1B genotype on lipid levels in response to 2 year weight-loss diets. J Lipid ResJ Lipid ResJ Lipid Res. 2018;59:155-161.

摘要:

Compelling evidence indicates that lipid metabolism is in partial control of the circadian system. In this context, it has been reported that the melatonin receptor 1B (MTNR1B) genetic variant influences the dynamics of melatonin secretion, which is involved in the circadian system as a chronobiotic. The objective was to analyze whether the MTNR1B rs10830963 genetic variant was related to changes in lipid levels in response to dietary interventions with different macronutrient distribution in 722 overweight/obese subjects from the POUNDS Lost trial. We did not find a significant association between the MTNR1B genotype and changes in lipid metabolism. However, dietary fat intake significantly modified genetic effects on 2 year changes in total and LDL cholesterol (P interaction = 0.006 and 0.001, respectively). In the low-fat diet group, carriers of the sleep disruption G allele (minor allele) showed a greater reduction of total cholesterol (beta +/- SE = -5.78 +/- 2.88 mg/dl, P = 0.04) and LDL cholesterol (beta +/- SE = -7.19 +/- 2.37 mg/dl, P = 0.003). Conversely, in the high-fat diet group, subjects carrying the G allele evidenced a smaller decrease in total cholesterol (beta +/- SE = 5.81 +/- 2.65 mg/dl, P = 0.03) and LDL cholesterol (beta +/- SE = 5.23 +/- 2.21 mg/dl, P = 0.002). Subjects carrying the G allele of the circadian rhythm-related MTNR1B variant may present a bigger impact on total and LDL cholesterol when undertaking an energy-restricted low-fat diet.

附注:

Goni, LeticiaSun, DianjianyiHeianza, YorikoWang, TiangeHuang, TaoCuervo, MartaMartinez, J AlfredoShang, XiaoyunBray, George ASacks, Frank MQi, LuR01 DK078616/DK/NIDDK NIH HHS/R01 DK091718/DK/NIDDK NIH HHS/P30 DK046200/DK/NIDDK NIH HHS/R21 HL126024/HL/NHLBI NIH HHS/R01 HL034594/HL/NHLBI NIH HHS/U01 DK078616/DK/NIDDK NIH HHS/R01 DK100383/DK/NIDDK NIH HHS/R01 HL071981/HL/NHLBI NIH HHS/J Lipid Res. 2018 Jan;59(1):155-161. doi: 10.1194/jlr.P078634. Epub 2017 Oct 31.