<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Goni, L.</style></author><author><style face="normal" font="default" size="100%">Sun, D.</style></author><author><style face="normal" font="default" size="100%">Heianza, Y.</style></author><author><style face="normal" font="default" size="100%">T. Wang</style></author><author><style face="normal" font="default" size="100%">Huang, T.</style></author><author><style face="normal" font="default" size="100%">Cuervo, M.</style></author><author><style face="normal" font="default" size="100%">Martinez, J. A.</style></author><author><style face="normal" font="default" size="100%">Shang, X.</style></author><author><style face="normal" font="default" size="100%">Bray, G. A.</style></author><author><style face="normal" font="default" size="100%">Sacks, F. M.</style></author><author><style face="normal" font="default" size="100%">Qi, L.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Macronutrient-specific effect of the MTNR1B genotype on lipid levels in response to 2 year weight-loss diets</style></title><secondary-title><style face="normal" font="default" size="100%">J Lipid ResJ Lipid ResJ Lipid Res</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Journal of lipid research</style></alt-title><short-title><style face="normal" font="default" size="100%">Journal of lipid researchJournal of lipid research</style></short-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">1</style></number><edition><style face="normal" font="default" size="100%">2017/11/02</style></edition><volume><style face="normal" font="default" size="100%">59</style></volume><pages><style face="normal" font="default" size="100%">155-161</style></pages><isbn><style face="normal" font="default" size="100%">1539-7262 (Electronic)0022-2275 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Compelling evidence indicates that lipid metabolism is in partial control of the circadian system. In this context, it has been reported that the melatonin receptor 1B (MTNR1B) genetic variant influences the dynamics of melatonin secretion, which is involved in the circadian system as a chronobiotic. The objective was to analyze whether the MTNR1B rs10830963 genetic variant was related to changes in lipid levels in response to dietary interventions with different macronutrient distribution in 722 overweight/obese subjects from the POUNDS Lost trial. We did not find a significant association between the MTNR1B genotype and changes in lipid metabolism. However, dietary fat intake significantly modified genetic effects on 2 year changes in total and LDL cholesterol (P interaction = 0.006 and 0.001, respectively). In the low-fat diet group, carriers of the sleep disruption G allele (minor allele) showed a greater reduction of total cholesterol (beta +/- SE = -5.78 +/- 2.88 mg/dl, P = 0.04) and LDL cholesterol (beta +/- SE = -7.19 +/- 2.37 mg/dl, P = 0.003). Conversely, in the high-fat diet group, subjects carrying the G allele evidenced a smaller decrease in total cholesterol (beta +/- SE = 5.81 +/- 2.65 mg/dl, P = 0.03) and LDL cholesterol (beta +/- SE = 5.23 +/- 2.21 mg/dl, P = 0.002). Subjects carrying the G allele of the circadian rhythm-related MTNR1B variant may present a bigger impact on total and LDL cholesterol when undertaking an energy-restricted low-fat diet.</style></abstract><accession-num><style face="normal" font="default" size="100%">29089366</style></accession-num><notes><style face="normal" font="default" size="100%">Goni, LeticiaSun, DianjianyiHeianza, YorikoWang, TiangeHuang, TaoCuervo, MartaMartinez, J AlfredoShang, XiaoyunBray, George ASacks, Frank MQi, LuR01 DK078616/DK/NIDDK NIH HHS/R01 DK091718/DK/NIDDK NIH HHS/P30 DK046200/DK/NIDDK NIH HHS/R21 HL126024/HL/NHLBI NIH HHS/R01 HL034594/HL/NHLBI NIH HHS/U01 DK078616/DK/NIDDK NIH HHS/R01 DK100383/DK/NIDDK NIH HHS/R01 HL071981/HL/NHLBI NIH HHS/J Lipid Res. 2018 Jan;59(1):155-161. doi: 10.1194/jlr.P078634. Epub 2017 Oct 31.</style></notes><custom2><style face="normal" font="default" size="100%">5748506</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Nutrition, Food Sciences, and Physiology University of Navarra, Pamplona, Navarra, Spain.Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, Navarra, Spain.Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.Epidemiology Domain, Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, Spain.Navarra Institute for Health Research, Pamplona, Navarra, Spain.Children&amp;#039;s Hospital New Orleans, New Orleans, LA.Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA.Departments of Nutrition Harvard T. H. Chan School of Public Health, Boston, MA.Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA lqi1@tulane.edu.Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.Channing Laboratory, Brigham and Women&amp;#039;s Hospital and Harvard Medical School, Boston, MA.</style></auth-address></record></records></xml>