开发目的：为定量评估肿瘤靶区（GTV）与关键危及器官（OAR）的空间位置关系，提供基于距离的剂量限量参考软件的主要功能：1. 自动提取RTSTRUCT中的危及器官（如视神经）和靶区（GTV）轮廓数据；2. 基于参考CT空间构建三维解剖结构Mask；3. 利用欧氏距离变换算法（Euclidean Distance Transform）计算危及器官的三维距离场；4. 自动判断肿瘤偏侧性（左/右），提取GTV体内素到对应危及器官的最短距离；5. 生成距离分布直方图（总体、分侧、个体）及详细统计报表（最小/平均距离等）。软件的技术特点：1.算法先进：采用SciPy高效距离变换算法，计算速度快，精度达体素级；2.自动化识别：支持模糊匹配ROI名称，自动处理左右侧器官对应关系；3.可视化丰富：高质量的距离分布直方图和累积分布曲线，直观展示空间关系

开发目的：为解决放疗中多患者靶区分布规律分析困难的问题，实现从多患者DICOM数据到统一参考空间热力图的自动化生成软件的主要功能：1. 自动化解析多患者DICOM数据（CT, RTSTRUCT, REG）；2. 基于刚性配准矩阵将不同患者的ROI轮廓变换到统一的参考CT空间；3. 支持批量处理和变换方向自动识别；4. 将变换后的矢量轮廓栅格化为二值Mask；5. 叠加多患者Mask生成概率分布热力图；6. 输出与参考CT共空间的NIfTI格式热力图，便于在三维可视化软件中显示。软件的技术特点：1. 自动化程度高：一键完成从DICOM解析、配准变换到热力图生成的全流程；2. 兼容性强：支持主流REG配准文件解析；3. 精度高：采用三维空间坐标变换算法和高精度栅格化技术；4. 扩展性好：基于Python模块化设计。

A novel, rapid, and efficient technique for removing phoxim residues from grapes was developed using microbubbles plasma-activated water (mbPAW). The mbPAW system was generated by utilizing a non-thermal plasma jet as the working gas of the Venturi tube. The phoxim residues in the grapes were quantified using high-performance liquid chromatography. Results indicated that the mbPAW treatment significantly enhanced the removal efficiency of the phoxim residues in grapes (92.82 %) compared with plasma-activated water (PAW) treatment (73.60 %) and microbubble generator without the plasma (mbW) treatment (13.56 %). The improved decontamination efficacy of mbPAW was attributed to its stronger oxidation capability and acidic environment, particularly the increased concentration of hydroxyl radicals, which facilitated phoxim removal from the grapes. Notably, LC-Q-TOF analysis revealed identical degradation products of phoxim (diethyl (Z)-(((cyano (phenyl)methylene)amino)oxy)phosphonate and (Z)-N-hydroxybenzimidoyl cyanide) in both the systems, confirming consistent degradation pathways. Crucially, post-treatment quality assessments revealed no statistically significant differences in grape physicochemical properties, including color, firmness, sugar content, vitamin C concentration, and superoxide dismutase activity. This study establishes mbPAW as a green, residue-free strategy for pesticide decontamination in horticultural products, offering high removal efficiency with minimal adverse impacts on produce quality.

本发明公开了一种基于空间距离分析的肿瘤放疗计划危及器官限量评价方法、装置及设备，涉及肿瘤放射治疗技术领域。具体地，仅依据几何统计量，在剂量计算之前使用三维欧氏距离变换在各向异性归一后得到危及器官全体素到靶区的最短距离分布，直接形成个体化限量与权重模板。本发明输出的对象是距离‑体素直方图及其派生的累计占比与变化率，并从中提取若干几何指标，结合预设的几何规则集，直接得到对应不同剂量的限量阈值及优化权重的个体化建议。与现有技术相比，本发明不做剂量预测，且无需生成辅助轮廓或者进行剂量前向/逆向计算，而是在剂量计算之前即可得到个体化可执行的限量与权重建议，显著减少优化迭代并提升一致性，且结果可解释性强。

开发目的：用于肿瘤自适应ART（Adaptive Radiation Therapy）放疗过程中各步骤耗时的精确记录、数据管理和统计分析，优化临床工作流程，提升放疗效率和质量 主要功能： 1. 实时计时功能：记录ART放疗过程中各步骤的时间戳，包括摆位、IGRT扫描、ROI生成、CTV/OARs勾画与修改、计划创建与优化、计划评估等16个关键步骤。2. 患者信息管理：记录患者姓名、ID、ART分次、日期等基本信息。3. ART设置记录：记录扫描范围、扫描层厚、CTV生成方式、计划生成方式等参数。4. 数据导出：自动导出Excel格式数据，包含步骤耗时表和事件时间戳表。5. 数据合并：合并多个Excel记录文件，生成统一的数据汇总表。6. 统计分析：计算各步骤的平均值、中位数、标准差、方差、最小值、最大值等统计指标。7. 数据可视化：生成箱线图、折线图等可视化图表，支持3mm与5mm扫描层厚的对比分析，包含显著性检验。8. 参考耗时对比：显示实际耗时与参考耗时的对比，用颜色标识是否超出参考时间。 技术特点：1. 采用面向对象设计，模块化架构，代码结构清晰。2. 实时计时更新机制，每秒自动刷新显示当前耗时。3. 支持键盘快捷键操作（Page Down/Up），提高操作效率。4. 自动数据导出和格式化，支持Excel多工作表。5. 内置统计分析模块，无需外部统计软件。6. 数据可视化功能，支持箱线图、折线图、趋势分析。7. 支持PyInstaller打包为独立可执行文件，无需安装Python环境。8. 中英文列名自动转换，便于国际化应用。

Cold atmospheric plasma (CAP) has become a promising technology for enhancing the efficacy of radiotherapy (RT) in cancer treatment and repairing the subsequent side effects. This review summarizes the current research on the combination of CAP and RT, focusing on its radiosensitizing effect, the ability to repair radiation-induced injury, and the challenges and solutions in the clinical application and promotion of this direction. Reactive oxygen and nitrogen species (RONS) produced by CAP increase the sensitivity of tumor cells to radiation and reduce the damage of radiation to normal cells, thus improving the effects and safety of RT. In addition, CAP has been proven to promote the repair of radiation-induced skin damage, especially radiation dermatitis (RDs), a common side effect of RT that currently lacks effective treatment options. By alleviating RD and enhancing tissue regeneration, CAP provides a new treatment method for managing the adverse reactions of RT. Although it has broad prospects, some challenges hinder the wide application of CAP in clinical settings, including limited penetration depth, the lack of standardized dosimetry, and the intricate nature of its underlying molecular mechanisms. In addition, the standardization of CAP equipment, precise parameter control strategies, and long-term safety issues require further investigation. This review emphasizes the necessity of continuous exploration to improve the role of CAP in RT and provides insights for the development of more effective and safer cancer treatment methods.

开发目的：为肿瘤放疗科室提供统一的预约管理和信息展示服务，提升工作效率和管理水平主要功能：1. 统一身份认证：支持JWT Token认证，单点登录，一次认证可访问所有子系统；2. 权限管理：三级权限体系（超级管理员、管理员、普通用户），支持多系统精细化权限配置；3. 精准放疗预约：预约信息管理，包含患者信息、预约时间、治疗类型等；4. 定位手术预约：手术预约管理，支持手术类型、手术室、医生等信息；5. 病房信息显示：治疗信息管理和大屏展示；6. 后装治疗预约：后装治疗预约信息管理；7. IP白名单管理：严格的IP地址访问控制；8. 用户管理：用户信息、角色权限的增删改查。技术特点：采用B/S架构，基于Node.js和Express框架；JWT无状态身份认证；bcrypt密码加密；JSON轻量级数据存储；RESTful API设计；模块化架构，支持多子系统集成；实时数据同步；IP白名单安全控制；响应式Web界面设计。

本发明涉及一种柔性器件，具体涉及可定位且具备压力感应的柔性器件，具体为：柔性器件为三明治结构，中间一层为绝缘层，由高分子绝缘薄膜组成，厚度为0.1‑1mm；绝缘层的上、下两层为可导电的水凝胶；其中，上层水凝胶为位置和压力敏感层，且均匀内嵌2‑4个电极；下层水凝胶的内嵌一个电极。本发明还提出了一种柔性器件的测量系统，由位置测量模块和压力测量模块构成。本发明可以实现压力感应和定位于一身，制作方法简便、绿色环保、具有良好的生物相容性、柔软可拉伸、弹性好，在可穿戴设备和生物医学领域具有潜在应用。

本发明公开自由基美白凝胶及其制备方法。本发明的目的是利用等离子体和脉冲电场得到氧自由基和氮自由基为主要成分的自由基美白凝胶和美白水凝胶。制备方法为，由大气压条件下激发的低温等离子体和脉冲电场联合处理去离子水或0～2％的过氧化氢溶液或0～2％过氧化脲溶液获得自由基活化溶液，然后配与固定剂制成凝胶，安全易用、无毒、无腐蚀，具有显著的牙齿美白功效和明显的公共卫生价值。

Antifungal hydrogels with added antifungal drugs have received extensive attention from researchers due to their potential use in various applications, such as wound dressings and ultrasound gel pads. In this study, we proposed and designed an alternative antifungal hydrogel preparation strategy to obtain hydrogels with high antifungal abilities. We employed plasma-activated water (PAW) instead of water in the hydrogel polymerization process to prepare plasma-activated hydrogels (PAHs). Disc diffusion assay results revealed that PAH exhibits satisfactory antifungal activity. Interestingly, the oxidation–reduction potential (ORP) of the PAH was significantly lower than that of conventional polyacrylamide (PAAm) hydrogels, and we provided a possible reaction equation to explain the lower value of ORP in the PAH. Furthermore, using electron spin resonance (ESR) spectroscopy, the hydroxyl radical was detected in PAHs. Although the active ingredients in the hydrogel cannot be quantitatively measured, the hydroxyl radical and NO3– are speculated to be the main components of PAH with antifungal activity according to ESR spectroscopy and optical emission spectroscopy. Further experiments also showed that PAH has a longer antifungal lifetime than PAW. In summary, the proposed plasma-activated hydrogels can provide valuable preparation strategies for delivering antifungal capabilities and have many potential applications in biomedical fields.

In this study, we propose a novel strategy, plasma activated water (PAW) to reduce pesticide residues on agricultural products. To validate its feasibility and effectiveness, we employee high-performance liquid chromatography (HPLC) to detect phoxim on grapes. HPLC results suggest that the reduction of phoxim on grapes achieve 73.60% after treated 10 min by PAW prepared 30 min, and the concentration of phoxim decreased significantly (p <  0.05) with the preparation time of PAW. Furthermore, HPLC-MS analysis shows that the reduction effect of phoxim by PAW is dominated by the degradation of phoxim. Combined with analyzing the physicochemical properties of PAW, one possible degradation pathway is proposed under the present experimental conditions, mediated by reactive oxygen and nitrogen species. The acidic environment (pH < 3) and high oxidation capacity (ORP > 500 mV) are suggested to be a benefit to the reduction of phoxim. Besides, the experimental results regarding color, firmness, sugar, vitamin C, and superoxide dismutase of grapes demonstrate that the PAW treatment will not significantly affect the quality of grapes. In conclusion, phoxim pesticide residues on grapes could be effectively reduced by the PAW strategy and without a significant (p <  0.05) effect on grapes quality.

Molecularly imprinted polymer (MIP) films prepared by bulk polymerization suffer from numerous deficiencies, including poor mass transfer ability and difficulty in controlling reaction rate and film thickness, which usually result in poor repeatability. However, polymer film synthesized by electropolymerization methods benefit from high reproducibility, simplicity and rapidity of preparation. In the present study, an Au film served as the refractive index-sensitive metal film to couple with the light leaked out from optical fiber core and the electrode for electropolymerizing MIP film simultaneously. The manufactured probe exhibited satisfactory sensitivity and specificity. Furthermore, the surface morphology and functional groups of the synthesized MIP film were characterized by Atomic Force Microscopy (AFM) and Fourier transform infrared microspectroscopy (FTIR) for further insights into the adsorption and desorption processes. Given the low cost, label-free test, simple preparation process and fast response, this method has a potential application to monitor substances in complicated real samples for out-of-lab test in the future.

本系统以宽带低噪声放大器LMH6554，配合宽带数控增益放大器LMH6401、射频功率放大器AH101以及LC带通滤波器设计并实现增益可控的射频放大器。本系统性能优良，实现了33MHz~243MHz带宽；0~64dB增益调节范围、增益步进最小为1dB；通频带内增益起伏小于2dB；50Ω负载上最大输出电压有效值可达5V_rms。本系统经过最终的级联和调试，工作可靠，用户界面友好，完全满足题目中所有的指标要求，且部分指标如带宽范围、增益调节范围、通频带内平坦度、最大输出电压有效值等指标均超出题目要求。