科研成果

2014
Yang F, Zhou L, Wang Q, You X, Li Y, Zhao Y, Han X, Chang Z, He X, Cheng C, et al. NEXN inhibits GATA4 and leads to atrial septal defects inmice and humans. Cardiovascular Research. 2014;(2):228-237. SCI被引用次数:6.
2013
Hu F-Y, Wu C, Li Y, Xu K, Wang W-J, Cao H, Tian X-L. AGGF1 is a novel anti-inflammatory factor associated with TNF-α-induced endothelial activation. Cellular Signalling [Internet]. 2013;(8):1645-165. 访问链接 SCI被引用次数:19.
Wang W-J, Han P, Zheng J, Hu F-Y, Zhu Y, Xie J-S, Guo J, Zhang Z, Dong J, Zheng G-Y, et al. Exon 47 skipping of fibrillin-1 leads preferentially to cardiovascular defects in patients with thoracic aortic aneurysms and dissections. Journal of Molecular Medicine [Internet]. 2013;(1):37-47. 访问链接 SCI被引用次数:15.
Zeng Y, Cheng L, Zhao L, Tan Q, Feng Q, Chen H, Shen K, Li J, Zhang F, Cao H, et al. Interactions between Social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China. BMC Geriatrics [Internet]. 2013;(1). 访问链接 SCI被引用次数:5.
Yang F, Wu M, Li Y, Zheng G-Y, Cao H-Q, Sun W, Yang R, Zhang H, Sheng Y-H, Kong X-Q, et al. Mutation p.S335X in GATA4 reduces its DNA binding affinity and enhances cell apoptosis associated with ventricular septal defect. Current Molecular Medicine. 2013;(6):993-999.
Wu C, Yan H, Sun J, Yang F, Song C, Jiang F, Li Y, Dong J, Zheng G-Y, Tian X-L, et al. NEXN is a novel susceptibility gene for coronary artery disease in Han Chinese. PLoS ONE. 2013;(12). SCI被引用次数:6.
2012
Zhao L, Yang F, Xu K, Cao H, Zheng G-Y, Zhang Y, Li J, Cui H, Chen X, Zhu Z, et al. Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging Cell [Internet]. 2012;(6):1094-1101. 访问链接 SCI被引用次数:15.
Gombar S, Jung HJ, Dong F, Calder B, Atzmon G, Barzilai N, Tian X-L, Pothof J, Hoeijmakers JHJ, Campisi J, et al. Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics [Internet]. 2012;(1). 访问链接 SCI被引用次数:41.
Dong W, Yang Z, Yang F, Wang J, Zhuang Y, Xu C, Zhang B, Tian X-L, Liu D. Suppression of Rap1 Impairs Cardiac Myofibrils and Conduction System in Zebrafish. PLoS ONE [Internet]. 2012;(11). 访问链接 SCI被引用次数:6.
Chen L-Y, Zhao W-H, Tian W, Guo J, Jiang F, Jin L-J, Sun Y-X, Chen K-M, An L-L, Li G-D, et al. STK39 is an independent risk factor for male hypertension in Han Chinese. International Journal of Cardiology [Internet]. 2012;(2):122-127. 访问链接
2011
Jiang F, Dong Y, Wu C, Yang X, Zhao L, Guo J, Li Y, Dong J, Zheng G-Y, Cao H, et al. Fine mapping of chromosome 3q22.3 identifies two haplotype blocks in ESYT3 associated with coronary artery disease in female Han Chinese. Atherosclerosis [Internet]. 2011;(2):397-403. 访问链接 SCI被引用次数:11.
Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, et al. Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Research [Internet]. 2011;(9):1295-1304. 访问链接 SCI被引用次数:83.
2010
Zeng Y, Cheng L, Chen H, Cao H, Hauser ER, Liu Y, Xiao Z, Tan Q, Tian X-L, Vaupel JW. Effects of FOXO genotypes on longevity: A biodemographic analysis. Journals of Gerontology - Series A Biological Sciences and Medical Sciences [Internet]. 2010;(12):1285-1299. 访问链接 SCI被引用次数:45.
2009
Li Y, Wang W-J, Cao H, Lu J, Wu C, Hu F-Y, Guo J, Zhao L, Yang F, Zhang Y-X, et al. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Human Molecular Genetics [Internet]. 2009;(24):4897-4904. 访问链接 SCI被引用次数:167.
2007
Zhang T, Yong SL, Tian X-L, Wang QK. Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice. Biochemical and Biophysical Research Communications [Internet]. 2007;(2):444-450. 访问链接 SCI被引用次数:23.
Tian X-L, Cheng Y, Zhang T, Liao M-LC, Yong SL, Wang QK. Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S. Biochemical and Biophysical Research Communications [Internet]. 2007;(4):879-883. 访问链接 SCI被引用次数:10.
2006
Tian X-L, Wang QK. Generation of transgenic mice for cardiovascular research. Methods in molecular medicine [Internet]. 2006:69-81. 访问链接
2004
Pokharel S, Geel PVP, Sharma UC, Cleutjens JPM, Bohnemeier H, Tian X-L, Schunkert H, Crijns HJGM, Paul M, Pinto YM. Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3. Circulation [Internet]. 2004;(19):3129-3135. 访问链接 SCI被引用次数:52.
Tian X-L, Pinto YM, Costerousse O, Franz WM, Lippoldt A, Hoffmann S, Unger T, Paul M. Over-expression of angiotensin converting enzyme-1 augments cardiac hypertrophy in transgenic rats. Human Molecular Genetics [Internet]. 2004;(14):1441-1450. 访问链接 SCI被引用次数:27.
Tian X-L, Kadaba R, You S-A, Liu H, Timur AA, Yang L, Chen Q, Szafranski P, Rao S, Wu L, et al. Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Nature [Internet]. 2004;(6975):640-645. 访问链接 SCI被引用次数:164.

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