科研成果 by Year: 2007

2007
Qiu X, Mercado-Feliciano M, Bigsby RM, Hites RA. Measurement of polybrominated diphenyl ethers and metabolites in mouse plasma after exposure to a commercial pentabromodiphenyl ether mixture. Environmental Health Perspectives. 2007;115:1052-1058.Abstract
BACKGROUND: Previous studies have shown that polybrominated diphenyl ethers (PBDEs) behave as weak estrogens in animal and cell culture bioassays. In vivo metabolites of PBDEs are suspected to cause these effects. OBJECTIVES: To identify candidate metabolites, mouse plasma samples were collected after continuous oral and subcutaneous exposure to DE-71, a widely used commercial pentabromodiphenyl ether product, for 34 days. METHODS: Samples were extracted, separated into neutral and phenolic fractions, and analyzed by gas chromatographic mass spectrometry. RESULTS: In the plasma samples of orally treated animals, 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153) represented 52% of total measurable PBDEs, whereas it represented only 4.3% in the DE-71 mixture. This suggested that BDE-153 was more persistent than other congeners in mice. Several metabolites were detected and quantitated: 2,4-dibromophenol, 2,4,5-tribromophenol, and six hydroxylated PBDEs. The presence of the two phenols suggested cleavage of the ether bond of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and 2,2',4,4',5-pentabromodipheny ether (BDE-99), respectively. The hydroxylated (HO)-PBDEs might come from hydroxylation or debromination/hydroxylation. Among the quantitated hydroxylated metabolites, the most abundant was 4-HO-2,2',3,4'-tetra-BDE, which suggested that there was a bromine shift during the hydroxylation process. para-HO-PBDEs have been proposed to behave as endocrine disruptors. CONCLUSIONS: There seem to be three metabolic pathways: cleavage of the diphenyl ether bond, hydroxylation, and debromination/hydroxylation. The cleavage of the diphenyl ether bond formed bromophenols, and the other two pathways formed hydroxylated PBDEs, of which,para-HO-PBDEs are most likely formed from BDE-47. These metabolites may be the most thyroxine-like and/or estrogen-like congeners among the HO-PBDEs.
Song J, Sun Q-F, Gao J, Xie XC. Measuring the phonon-assisted spectral function by using a nonequilibrium three-terminal single-molecular device. Physical Review B - Condensed Matter and Materials Physics. 2007;(19).
Qi B, Chao YT, Chen ZM. Mechanism and kinetics of the production of hydroxymethyl hydroperoxide in ethene/ozone/water gas-phase system. Science in China Series B-Chemistry. 2007;50(3):425-431.
Zhu H, Hu G-Q, Yang Y-F, Wang J, She Z-S. MED: A new non-supervised gene prediction algorithm for bacterial and archaeal genomes. BMC Bioinformatics [Internet]. 2007. 访问链接
Li J, Wang G, Wang C, Zhao Y, Zhang H, Tan Z, Song Z, Ding M, Deng H. MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal. Differentiation [Internet]. 2007;(4):299-307. 访问链接
Yang X-H, Deng W, Tong Z, Liu Y-X, Zhang L-F, Zhu H, Gao H, Huang L, Liu Y-I, Ma C-M, et al. Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection. Comparative Medicine [Internet]. 2007;(5):450-459. 访问链接
Xu L, Robert L, Ouyang Q, Taddei F, Chen Y, Lindner AB, Baigl D. Microcontact printing of living bacteria arrays with cellular resolution. Nano Letters [Internet]. 2007;(7):2068-2072. 访问链接
Wang ZM, Bao K, Xu LP, Luo CX, Zhang B, Ji H, Ouyang Q, Chen Y. Microfluidic cooling of semiconductor light emission diodes. Microelectronic Engineering. 2007;(5-8):1223-1226.
Guo X, Chen K-H, Guo Y, Liao H, Tang J, Xiao R-P. Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway. Circulation Research [Internet]. 2007;(11):1113-1122. 访问链接
Shen T, Zheng M, Cao C, Chen C, Tang J, Zhang W, Cheng H, Chen K-H, Xiao R-P. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. Journal of Biological Chemistry [Internet]. 2007;(32):23354-23361. 访问链接
Shen T, Zheng M, Cao C, Chen C, Tang J, Zhang W, Cheng H, Chen K-H, Xiao R-P. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. Journal of Biological Chemistry [Internet]. 2007;(32):23354-23361. 访问链接
Shen T, Zheng M, Cao C, Chen C, Tang J, Zhang W, Cheng H, Chen K-H, Xiao R-P. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. Journal of Biological Chemistry [Internet]. 2007;(32):23354-23361. 访问链接
Shen T, Zheng M, Cao C, Chen C, Tang J, Zhang W, Cheng H, Chen K-H, Xiao R-P. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. Journal of Biological Chemistry [Internet]. 2007;(32):23354-23361. 访问链接
Zanardi P, Quan HT, Wang X, Sun CP. Mixed-state fidelity and quantum criticality at finite temperature. 2007;(3).
Li H, Guo H. Molecular basis of the ethylene signaling and response pathway in Arabidopsis. Journal of Plant Growth Regulation. 2007;(2):106-117.
Song Y, Fee L, Lee TH, Wharton RP. The molecular chaperone Hsp90 is required for mRNA localization in Drosophila melanogaster embryos. Genetics [Internet]. 2007;(4):2213-2222. 访问链接
Zhang Z, Chen H, Bai H, Lai L. Molecular dynamics simulations on the oligomer-formation process of the GNNQQNY peptide from yeast prion protein Sup35. Biophysical Journal [Internet]. 2007;(5):1484-1492. 访问链接
Wang J, Wen HS, Jin YJ, Brandt-Rauf PW, Yin Y. A molecular link between E2F-1 and the MAPK cascade. Journal of Biological Chemistry [Internet]. 2007;(25):18521-18531. 访问链接
Wang C, Faloon PW, Tan Z, Lv Y, Zhang P, Ge Y, Deng H, Xiong J-W. Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. Blood [Internet]. 2007;(10):3601-3609. 访问链接
Wang C, Faloon PW, Tan Z, Lv Y, Zhang P, Ge Y, Deng H, Xiong J-W. Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. Blood [Internet]. 2007;(10):3601-3609. 访问链接

Pages