Silicate Earth is widely considered identical to chondrites in its refractory lithophile element ratios. However, its subchondritic Nb/Ta signature deviates from the chondritic paradigm. To resolve this Nb deficit, its sequestration in Earth's core under very reducing core-forming conditions has been proposed based on low-pressure data. Here, we show that under conditions relevant to core formation Nb is siderophile at high pressures under all redox conditions, corroborating Nb inventory in Earth's core. Further core formation modeling shows that Earth's core could have formed under moderately reducing or oxidizing conditions, whereas highly reducing conditions mismatch the geochemical observables; although Earth may have sampled a variety of reservoirs, it is problematic to accrete primarily from materials as reduced as enstatite chondrites.
In this study, three pilot-scale solid-phase denitrification (SPD) systems filled with poly-3-hydroxybutyrate-co-hyroxyvelate (PHBV), PHBV-Rice hulls (PHBV-RH) and PHBV-Sawdust (PHBV-S) were operated to treat effluent of waste water treatment pangts (WWTPs). The fast start-up and intensified nitrogen removal performance were obtained in PHBV-RH and PHBV-S systems. Besides, the optimal total nitrogen (TN) removal efficiency was obtained in PHBV-S system (91.65 +/- 4.12%) with less ammonia accumulation and dissolved organic carbon (DOC) release. The significant enrichment of amx 16S rRNA and nirS genes in PHBV-RH and PHBV-S systems indicated the possible coexistence of anammox and denitrification. Miseq sequencing analysis exhibited more complex community diversity, more abundant denitrifying and fermenting bacteria in PHBV-RH and PHBV-S systems. The co-existence of denitrification and anammox might contribute to better control of nitrogen and dissolved organic carbon in PHBV-S system. The outcomes provide an economical and eco-friendly alternative to improve nitrogen removal of WWTPs effluent.
The oxidation of nitric oxide to nitrogen dioxide by hydroperoxy (HO2) and organic peroxy radicals (RO2) is responsible for the chemical net ozone production in the troposphere and for the regeneration of hydroxyl radicals, the most important oxidant in the atmosphere. In Summer 2014, a field campaign was conducted in the North China Plain, where increasingly severe ozone pollution has been experienced in the last years. Chemical conditions in the campaign were representative for this area. Radical and trace gas concentrations were measured, allowing for calculating the turnover rates of gas-phase radical reactions. Therefor; the importance of heterogeneous HO(2 )uptake on aerosol could be experimentally determined. HO2 uptake could have suppressed ozone formation at that time because of the competition with gas-phase reactions that produce ozone. The successful reduction of the aerosol load in the North China Plain in the last years could have led to a significant decrease of HO2 loss on particles, so that ozone-forming reactions could have gained importance in the last years. However, the analysis of the measured radical budget in this campaign shows that HO2 aerosol uptake did not impact radical chemistry for chemical conditions in 2014. Therefore, reduced HO2 uptake on aerosol since then is likely not the reason for the increasing number of ozone pollution events in the North China Plain, contradicting conclusions made from model calculations reported in the literature.
During the EXPLORE-YRD campaign (EXPeriment on the eLucidation of the atmospheric Oxidation capacity and aerosol foRmation, and their Effects in Yangtze River Delta) in May June 2018, we measured N2O5, NO2, O-3 and relevant parameters at a regional site in Taizhou, Jiangsu Province. The nocturnal average NO3 production rate was 1.01 +/- 0.47 ppbvh(-1), but the mixing ratio of N2O5 was low, with a maximum of 220 pptv in 1 min, suggesting rapid loss of NO3 and N2O5. The nocturnal steady-state lifetime of N2O5 was 43 + 52 s on average, which may be attributed to the elevated monoterpene and fast N2O5 uptake. VOCs (mainly monoterpenes) dominated daily NO3 loss with the percentage of 36.4% and N2O5 uptake accounted for 14.4%, when taking NO + NO3 and NO3 photolysis into consideration. We demonstrated that the nonnegligible daytime NO3 oxidation of monoterpene in YRD region, which contributes to the daytime formation of organic nitrate and secondary organic aerosol. The daily average NOx consumption rate via rapid NO3 reaction reached 0.63 ppbvh(-1), corresponding to 57.3% NOx loss in comparison with the OH oxidation pathway at this site, highlighting the key role of NO3 and N2O5 in NOx removal and subsequent photochemistry in the YRD region.
Numerous experimental studies suggest that noise is inherent in the human brain. However, the functional importance of noise remains unknown. n particular, from a computational perspective, such stochasticity is potentially harmful to brain function. In machine learning, a large number of saddle points are surrounded by high error plateaus and give the illusion of the existence of local minimum. As a result, being trapped in the saddle points can dramatically impair learning and adding noise will attack such saddle point problems in high-dimensional optimization, especially under the strict saddle condition. Motivated by these arguments, we propose one biologically plausible noise structure and demonstrate that noise can efficiently improve the optimization performance of spiking neural networks based on stochastic gradient descent. The strict saddle condition for synaptic plasticity is deduced, and under such conditions, noise can help optimization escape from saddle points on high dimensional domains. The theoretical results explain the stochasticity of synapses and guide us on how to make use of noise. In addition, we provide biological interpretations of proposed noise structures from two points: one based on the free energy principle in neuroscience and another based on observations of in vivo experiments. Our simulation results manifest that in the learning and test phase, the accuracy of synaptic sampling with noise is almost 20% higher than that without noise for synthesis dataset, and the gain in accuracy with/without noise is at least 10% for the MNIST and CIFAR-10 dataset. Our study provides a new learning framework for the brain and sheds new light on deep noisy spiking neural networks.
A series of CuCo2O4 composite spinels with an interconnected meso-macroporous nanosheet morphology were synthesized using the hydrothermal method and subsequent calcination treatment to activate peroxymonosulfate (PMS) for benzophenone-4 (BP-4) degradation. As-prepared CuCo2O4 composite spinels, especially CuCo-H3 prepared by adding cetyltrimethylammonium bromide, showed superior reactivity for PMS activation. In a typical reaction, BP-4 (10.0 mg/L) was almost completely degraded in 15 min by the activation of PMS (200.0 mg/L) using CuCo-H3 (100.0 mg/L), with only 9.2 μg/L cobalt leaching detected. Even after being used six times, the performance was not influenced by the lower leaching of ions and surface-absorbed intermediates. The possible interface mechanism of PMS activation by CuCo-H3 was proposed, wherein a unique interconnected meso-macroporous nanosheet structure, strong interactions between copper and cobalt, and cycling of Co(II)/Co(III) and Cu(I)/Cu(II) effectively facilitated PMS activation to generate SO4•– and •OH, which contributed to BP-4 degradation. Furthermore, combined with intermediates detected by liquid chromatography quadrupole time-of-flight mass spectrometry and density functional theory calculation results, the degradation pathway of BP-4 involving hydroxylation and C–C bond cleavage was proposed.
With the development of the times, the demand for rapid detection of trace toxic and harmful components and circulating tumor cells is increasing and it is urgent to develop portable specialized detection instruments. Since it is difficult to directly measure the sample material in the trace amount detection, the method of high-enrichment of the trace substance based on the ion concentration polarization principle can make the trace substance easy to be determined. In this paper, a novel micro-nanofuidic preconcentrator with Koch fractal nanochannel surface is proposed. By coupling the Poisson-Nernst-Planck equation and the Navier-Stokes equation, the influence of Koch fractal parameters on ion enrichment was studied by numerical simulation. The results show that increasing the unit length L, increasing fractal time n, using the unstraggered structure and increasing the fractal angle theta can significantly increase the ion enrichment ratio. In addition, we found that the above means can reduce the fluid flow velocity in the nanochannel and thus reduce the negative influence of electroosmotic flow on ion enrichment. This work provides a theoretical basis for the design of trace detection instruments based on micro-nanofluidic platform.
Glyoxal (GLY) and methylglyoxal (MGLY), as tracers of oxidation of volatile organic compounds (VOCs), play an important role in atmospheric chemistry. In this work, the concentrations of these two aldehydes were simultaneously measured online at a regional site in Jiangsu Province (China) during the 2018 EXPLORE-YRD campaign. The maximum measured concentration of GLY and MGLY was 0.47 and 6.68 ppb, respectively. As the campaign site was surrounded by farmland and the observations were recorded during harvest, significant enhancements to the concentration of GLY and MGLY were found owing to agricultural biomass burning. While the enhancement of MGLY relative to CO (0.0059 ± 0.0012) was found to be consistent with previous study, the corresponding enhancement ratios of GLY were lower (0.0003 ± 0.0001). The possibility of using the ratios between formaldehyde (HCHO), GLY, and MGLY concentrations as indicators of reactive VOC composition was investigated. Based on measured data and model simulation results, we found that the MGLY to HCHO ratio was sensitive to VOC precursors and reasonably well correlated with the reactivity of aromatics.
Glyoxal (GLY) and methylglyoxal (MGLY), as tracers of oxidation of volatile organic compounds (VOCs), play an important role in atmospheric chemistry. In this work, the concentrations of these two aldehydes were simultaneously measured online at a regional site in Jiangsu Province (China) during the 2018 EXPLORE-YRD campaign. The maximum measured concentration of GLY and MGLY was 0.47 and 6.68 ppb, respectively. As the campaign site was surrounded by farmland and the observations were recorded during harvest, significant enhancements to the concentration of GLY and MGLY were found owing to agricultural biomass burning. While the enhancement of MGLY relative to CO (0.0059 +/- 0.0012) was found to be consistent with previous study, the corresponding enhancement ratios of GLY were lower (0.0003 +/- 0.0001). The possibility of using the ratios between formaldehyde (HCHO), GLY, and MGLY concentrations as indicators of reactive VOC composition was investigated. Based on measured data and model simulation results, we found that the MGLY to HCHO ratio was sensitive to VOC precursors and reasonably well correlated with the reactivity of aromatics.
Background/purpose: Occult HBV infection (OBI) could have serious clinical consequences in patients receiving immunosuppressive therapy. We aimed to investigate the prevalence of OBI in Chinese patients with autoimmune hepatitis (AIH) and to analyze its clinical and virological features.
Methods: 103 AIH cases were enrolled. Hepatitis B virus (HBV) serological markers were screened by chemiluminescence. HBV-DNA were detected by nest-PCR and real-time PCR. HBV genotyping and mutation analysis were performed by Sanger sequencing.
Results: Twenty-four out of 103 (23.30%) AIH patients had OBI as evidenced by positive HBV-DNA and negative hepatitis B surface antigen (HBsAg). HBV genotype C is the predominant genotype (57.89%), which had more amino acid (AA) substitutions in S region than that of B-genotype group (P = 0.001). The distribution of AA substitution in the 'α' determinant region between genotype C and B were significantly different (P = 0.042). In addition to those already reported OBI-associated AA substitutions (e.g., sG145R and sV184A), some new OBI-associated AA substitutions (e.g., sV106A, sC137* and sL176P) were found in AIH patients in our study. Three out of 24 (12.50%) OBI patients were diagnosed as decompensated cirrhosis, one patient with S deletion mutation and two patients with HBV extensive AA substitutions.
Conclusions: There was a higher proportion of AIH patients with OBI than the general population in China, which can be either seropositive or seronegative-OBI in AIH patients is associated with some specific AA substitutions. The presence of deletion mutations and the extent of AA substitutions in the HBV S region may have predictive clinical implications.
Keywords: Amino acid substitution; Autoimmune hepatitis; Occult HBV infection.
There is a dearth of information on the occurrence and risks of antibiotics in the urban rivers from plateau areas. This study investigated 83 antibiotics in water and sediments of an urban river and effluents of sewage treatment plants (E-STPs) in Xining, Qinghai (northeastern Tibetan Plateau). Fifty-three antibiotics were detected, and the concentrations of individual antibiotics varied in the range of undetected (ND)-552 ng/L in water, ND-164 ng/g in sediments, and ND-3821 ng/L in E-STPs. Seasonal differences of antibiotic concentrations were significant for water samples (p<0.05) but insignificant for sediments (p>0.05). In urban area, E-STP is the main source of antibiotics in the river, while runoff from manured cropland contributes partially to antibiotics in the river in the suburban area. The antibiotic compositions in water were different from those in sediments, but were similar to those in E-STPs. Notably, because of strong solar radiation and long sunshine hours in the plateau area, low levels of quinolones, which are sensitive to photolysis, were observed in river water. Moreover, norfloxacin and enrofloxacin, observed in urban river from other regions of China, were not detected in the Huangshui River water. The occurrence of ofloxacin, erythromycin, roxithromycin, clarithromycin, and trimethoprim in E-STPs may induce a possible risk to antibiotic resistance evolution. Trimethoprim, anhydroerythromycin, sulfamethoxazole, sulfapyridine, and clindamycin in river water could pose low to medium risks to aquatic organisms. Further investigation on the occurrence and distribution of antibiotic resistance genes in the Huangshui River is urgently needed.