Coastal sediment cores provide important records of land-based antibiotics' deposition. This study examined sediment cores from the Hangzhou Bay, East China Sea, dating back to 1980–2020 using 210Pbex. The 40-year analysis revealed a mismatch between sediment depth and age. Wastewater treatment facilities have significantly reduced antibiotics discharge into the sea. We identified 27 antibiotics, with enrofloxacin (ERFX) and nadifloxacin (NDFX) exhibiting the highest average concentrations of 84.9 and 83.4 ng/g, respectively. Quinolones (QNs) were prominent, displaying strong co-occurrence and similar distribution patterns shaped by comparable soil-water distribution coefficient (Kd). QNs correlated positively with total antibiotic concentration, serving as indicators. We proposed a multi-dimensional risk assessment of antibiotics, encompassing ecological and antimicrobial resistance (AMR) risks, complementing each other. The assessment revealed antibiotics with distinct risks: sulfacetamide (SCM) and clindamycin (CLIN) exhibited high ecological risks, while ERFX, ciprofloxacin (CFX), norfloxacin (NFX), gatifloxacin (GTFX), moxifloxacin (MXFX), and marbofloxacin (MBFX) presented high AMR risks.
Chen W, Zhang Z, Zhang X, Shen Q, Yarom Y, Genkin D, Yan C, Wang Z. HyperHammer: Breaking Free from KVM-Enforced Isolation, in Proceedings of the 30th ACM International Conference on Architectural Support for Programming Languages and Operating Systems, Volume 2, ASPLOS 2025, Rotterdam, Netherlands, 30 March 2025 - 3 April 2025. ACM; 2025:545–559. 访问链接
The digital economy has become a driving force for global economic development, resulting in high demand for balanced regional development. Using surname distance as a proxy variable for cultural distance, this study examined the impact of cultural differences on the development of a regional digital economy. The results of the analysis of panel data from 31 Chinese provinces from 2011 to 2019 indicated that the development of a region's digital economy positively contributes to the development of the digital economy in areas of cultural proximity. Further analysis of the mechanisms of cultural differences in the digital economy showed that cultural distance affects the development of the digital economy in a province through three mechanisms: birth rate, divorce rate, and the share of small families. Moreover, the findings suggest regional, divorce, and demographic heterogeneity in the impact of cultural distance on the digital economy.