While it has been acknowledged that exposure to endocrine-disrupting chemicals (EDCs) is associated with human diseases, the overall disease burden attributable to the exposure to a specific EDC has rarely been evaluated. Based on existing models for assessing probabilities of causation and a comprehensive review of available data, we analyzed the burden of three diseases, i.e., male infertility, adult obesity, and diabetes, among the general Chinese population resulting from exposure to phthalates. Our estimation indicates that exposure to phthalates is associated with ~2.50 million cases of the three diseases across China in 2010, causing ~57.2 billion Chinese Yuan (equivalent to ~9 billion US dollars) of health care costs in a year. Male infertility has the largest number of cases, followed by adult obesity and diabetes. Based on these phthalate-specific estimates, we further estimated that the total disease cost due to exposure to the overall EDCs amounted to ~429.43 billion Chinese Yuan in China in 2010, accounting for 1.07% of nationwide gross domestic product (GDP). When comparing our results with an earlier estimate for the European Union (EU) member countries, we find that exposure to phthalates leads to quite a similar disease burden per unit of GDP in both regions. Our study illustrates the considerable socio-economic impact of EDC exposure on human society, implying the imperative need for global risk reduction actions on EDCs, especially in view of the 2030 Sustainable Development Goals.
In this paper, a method for modeling distance dependent head-related transfer functions is presented. The HRTFs are first decomposed by spatial principal component analysis. Using deep neural networks, we model the spatial principal component weights of different distances. Then we realize the prediction of HRTFs in arbitrary spatial distances. The objective and subjective experiments are conducted to evaluate the proposed distance model and the distance variation function model, and the results have shown that the proposed model has less spectral distortions than distance variation function model, and the virtual sound generated by the proposed model has better performance in terms of distance localization.
Abstract Plant pathogens are increasingly considered as important agents in promoting plant coexistence, while plant symbionts like ectomycorrhizal fungi (EMF) can facilitate plant dominance by helping conspecific individuals to defend against plant pathogens. However, we know little about their relationships with plants at large scales. Here, using soil fungal data collected from 28 forest reserves across China, we explored the latitudinal diversity gradients of overall fungi and different fungal functional guilds, including putative plant pathogens, EMF and saprotrophic fungi. We further linked the spatial patterns of alpha diversities of putative plant pathogens and EMF to the variation of plant species richness. We found that the relationships between latitude and alpha diversities of putative plant pathogens and EMF were region-dependent with sharp diversity shifts around the mid-latitude (~ 35 oN), which differed from the unimodal diversity distributions of the overall and saprotrophic fungi. The variations in the diversities of putative plant pathogens and EMF were largely explained by the spatial regions (south Vs north / subtropical zone Vs temperate zone). Additionally, the alpha diversities of these two fungal guilds exhibited opposing trends across latitude. EMF could alter the relationship between diversities of putative plant pathogens and plants in the south/subtropical region, but not vice versa. We also found that the ratio of their alpha diversities (EMF to putative plant pathogens) was negatively related to plant species richness across the spatial regions (north to south), and explained ~10% of the variation of plant species richness. Overall, our findings suggest that plant-microbe interactions not only shape the local plant diversity but also may have non-negligible contributions to the large-scale patterns of plant diversity in forest ecosystems.
High efficiency organic-inorganic hybrid perovskite solar cells have attracted significant attention and experienced a rapid development in recent years. Lithium-doped spiro-OMeTAD is one of the most commonly used hole transporting material, however, the hygroscopicity of lithium dopant usually causes serious moisture instability of devices. Herein, we demonstrate a dopant-free spiro-OMeTAD as hole transporting layer to improve the ambient stability of planar perovskite solar cells. With the optimization of the thickness of spiro-OMeTAD layer, the dopant-free spiro-OMeTAD based device achieved a comparable device performance with a champion power conversion efficiency of 16.92%. Moreover, the unencapsulated dopant-free device showed significantly improved stability, which still maintained 95% of its initial efficiency after storage in ambient environment for 60 days. This work provides a simple and valid approach to overcome the instability issue of spiro-OMeTAD based devices, paving a way to manufacture more stable and efficient perovskite photovoltaics.
The Three Gorges Dam (TGD) has altered downstream flow–sediment regimes and led to significant changes in the morphodynamic processes in the Middle Yangtze River (MYR). However, due to the complexity of this large river, the driving forces and implication of the morphodynamic processes remain insufficiently understood. This study selected two typical meandering and bar-braided reaches, the Zhicheng (ZC) and Shashi (SS) reach, to examine their responses to the TGD operation. The results showed that in the post-dam period significant channel erosion occurred with a higher erosion rate in the ZC reach (closer to the TGD) compared with the SS reach. The area of the Guanzhou mid-channel bar (ZC reach) and the Sanba mid-channel bar (SS reach) shrank by 30 and 90% from 2003 to 2015, respectively. The increased fluvial erosion intensity due to the reduction in suspended sediment concentration (SSC) drove the shrinkage of the mid-channel bars, as demonstrated by empirical relationships between bar geometry and fluvial erosion intensity. An increase of 22 days per year in the frequency of post-dam medium-to-high discharges (10 000–25 000 m3 s−1), and associated with the reduction in SSC, jointly led to the greater erosion at the convex (inner) banks than the concave (outer) banks, which has negatively affected the designed navigation channels at the concave banks by decreasing their discharge partitioning ratios. The post-dam water level at a given high discharge (>25 000 m3 s−1) showed no evident change, but the water level at a given low discharge (<10 000 m3 s−1) decreased. The reduction in water levels at low flows can affect water supply and riverine ecosystems in the MYR.