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CV

  • Dean, Institute of Medical Technology, Peking University Health Science Center
  • Professor, Department of Radiology, Third Hospital of Peking University
  • Corresponding Academician, International Academy of Astronautics
  • Chairman, MRI Equipment and Technology Committee, Chinese Medical Equipment Association
  • Vice Chairman, National Education and Direction Committee for Medical Technology Professional Degree Graduate Student, PRC
  • Committee Member, Advisory Committee of Information Science Department, National Natural Science Foundation of China
  • Director, Key Laboratory of Medical Imaging Equipment Quality Control, National Health Commission of China
  • Director, Beijing Key Laboratory of MRI Equipment and Technology

Biography

Professor Hongbin Han has dedicated his career to advancing medical imaging technologies for the diagnosis and treatment of brain diseases. He is internationally recognized as a leading expert in the field of brain extracellular space according to global academic citation impact. He received numerous awards including the China Youth Science and Technology Award in 2011, the First Prize of Huaxia Medical Science and Technology Award in 2015, and the National Fund for Distinguished Young Scholars from NSFC (National Science Foundation of China) in 2016. His work was selected into the “Top Ten Medical Science and Technology News in China” in 2019. Since 2022, he has served as a Corresponding Academician of the International Academy of Astronautics, and received the First Prize in the Beijing Progress in Science and Technology Award in 2023.

Honors and Awards

  • First Prize, Beijing Progress in Science and Technology Award - 2022
  • Top Ten Medical Science and Technology News in China - 2019
  • First Prize, Huaxia Medical Science and Technology Award - 2015
  • China Excellent Youth Science and Technology Award - 2011

 

Selected Publications

  1. Zhang H, Fu Y, Han H*, Sun J*, Xie L*, Ren X, Yuan Y, Fu W, Mao X, Liu H, Cao J. Measurement of Extracellular Electrical Properties with Tracer-Based MRI. Sensing and Imaging. 2024 Jun 13;25(1):34. 
  2. Lian J, Yang L, Tan H, Su S, Serrano Lopes L, Cheng F, Yan J, Fu Y, Fu W, Xie Z, Sun J, Zhang J, Tong Z*, Gao Y*, Han H*. A novel neuroprotective method against ischemic stroke by accelerating the drainage of brain interstitial fluid. Sci China Life Sci. 2024 Aug 2. doi: 10.1007/s11427-024-2592-4.
  3. Shang K, Xu C, Cao Z, Cui M, Sun J, Xiao H, Zhang L*, Wang Y*, Han H*. Polymer-based delivery systems with metal complexes as contrast agents for medical imaging. Coordination Chemistry Reviews. 2024 Nov 1;518:216071..
  4. Xu L*, Wu Y, Shen X, Zhou L, Lu Y, Teng Z, Du J, Ding M, Han H, Niu T*. Exploring the biological basis of CT imaging features in pancreatic neuroendocrine tumors: a two-center study. Phys Med Biol. 2024 Jun 11;69(12). doi: 10.1088/1361-6560/ad51c7.
  5. Lei B, Li Y, Fu W, Yang P, Chen S, Wang T, Xiao X, Niu T, Fu Y*, Wang S*, Han H*, Qin J; Alzheimer’s Disease Neuroimaging Initiative. Alzheimer's disease diagnosis from multi-modal data via feature inductive learning and dual multilevel graph neural network. Med Image Anal. 2024 May 28;97:103213. doi: 10.1016/j.media.2024.103213.
  6. Xie J, Li H, Su S, Cheng J, Cai Q, Tan H, Zu L, Qu X, Han H*. Quantitative analysis of molecular transport in the extracellular space using physics-informed neural network. Comput Biol Med. 2024 Mar;171:108133. doi: 10.1016/j.compbiomed.2024.108133.
  7. Zhao G, Chen H, Yan J, Tong Z, Fu Y, Xie Z, Han H*. Efficacy of Citicoline Delivered via Brain Extracellular Space against Experimental Acute Ischemic Stroke in Rats. Int J Med Sci. 2024 May 13;21(7):1274-1279. doi: 10.7150/ijms.93482.
  8. Niu T*, Xu L, Ren Q, Gao Y, Luo C, Teng Z, Du J, Ding M, Xie J, Han H, Jiang Y. UBES: Unified scatter correction using ultrafast Boltzmann equation solver for conebeam CT. Comput Biol Med. 2024 Mar;170:108045. doi: 10.1016/j.compbiomed.2024.108045.
  9. Liu S, Liu T, Tian W, Zhang Q, Wang Z, Hou X, Ren Y, Yan W, Xu M, Han H*, Zhu H*. Unique role of molecular imaging probes for viral infection. TrAC Trends in Analytical Chemistry. 2023 Nov 29:117470.
  10. Xiang J, Mao A*, Xie J, Han H, Wang X, Jin P, Du J, Ding M, Yu L, Niu T*. DER-GAN: Dual-Energy Recovery GAN for Conebeam CT. IEEE Transactions on Computational Imaging. 2023 Dec 29.
  11. Ding L, Gu Z, Chen H, Wang P, Song Y, Zhang X, Li M, Chen J, Han H*, Cheng J*, Tong Z*. Phototherapy for age-related brain diseases: Challenges, successes and future. Ageing Res Rev. 2024 Feb; 94:102183. doi: 10.1016/j.arr.2024.102183.
  12. Lei B, Zhu Y, Liang E, Yang P, Chen S, Hu H, Xie H, Wei Z, Hao F, Song X, Wang T, Xiao X*, Wang S*, Han H*. Federated Domain Adaptation via Transformer for Multi-site Alzheimer's Disease Diagnosis. IEEE Trans Med Imaging. 2023 Aug doi: 10.1109/TMI.2023.3300725
  13. Zhang L, Shang K, Li X, Shen M, Lu S, Tang D, Han H*, Yu Y*. Reduction sensitive polymers delivering Cationic platinum drugs as STING agonists for enhanced chemo‐immunotherapy. Advanced Functional Materials. 2022 Oct;32(43):2204589.
  14. Shang K, Zhang L, Yu Y, Xiao H*, Gao Y, Yang L, Huang J*, Song H*, Han H*. Disulfide-containing polymer delivery of C527 and a Platinum(IV) prodrug selectively inhibited protein ubiquitination and tumor growth on cisplatin resistant and patient-derived liver cancer models. Mater Today Bio. 2023 Jan 13;18:100548.
  15. Zhang L, Zhu L, Tang L, Xie J, Gao Y, Yu C, Shang K*, Han H*, Liu C*, Lu Y. Glutathione-Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy. Adv Sci. 2023 Jan;10(3)
  16. Yang Y, Wang Y, Gao T, Reyila A, Liu J, Liu J*, Han H*. Effect of Physiotherapy Interventions on Motor Symptoms in People with Parkinson's Disease: A Systematic Review and Meta-Analysis. Biol Res Nurs. 2023 Apr 18:10998004231171587.
  17. Cao L, Tian H, Fang M, Xu Z, Tang D, Chen J, Yin J, Xiao H, Shang K*, Han H*, Li X*. Activating cGAS-STING pathway with ROS-responsive nanoparticles delivering a hybrid prodrug for enhanced chemo-immunotherapy. Biomaterials. 2022 Nov; 290:121856.
  18. Kou Y, Zhao H, Cui D, Han H*, Tong Z*: Formaldehyde toxicity in age-related neurological dementia. Ageing Research Reviews 2022, 73:101512-.
  19. 19. Liu S, Li G, Ding L, Ding J, Zhang Q, Li D, Hou X, Kong X, Zou J, Zhang S, Han H*, Wan Y*, Yang Z*, Zhu H*. Evaluation of SARS-CoV-2-Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice. Research (Wash D C). 2022 Jul 22; 2022:9864089.
  20. 20. Gu Z, Chen H, Zhao H, Yang W, Song Y, Li X, Wang Y, Du D, Liao H, Pan W, Li X, Gao Y, Han H, Tong Z*. New insight into brain disease therapy: nanomedicines-crossing blood-brain barrier and extracellular space for drug delivery. Expert Opin Drug Deliv. 2022 Dec;19(12):1618-1635.
  21. Ablat N, Liu R, Ablimit M, Sun Y, Xu F, Zhao X*, Han H*, Pu X*: Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease rat model. Neuropharmacology 2022, 217:109209.
  22. Gao Y, Han H*, Du J, He Q, Jia Y, Yan J, Dai H, Cui B, Yang J, Wei X, Yang L. Early changes to the extracellular space in the hippocampus under simulated microgravity conditions. Science China Life Sciences. 2022 Mar;65(3):604-17.
  23. Wang R, Han H*, Shi K, Alberts IL, Rominger A, Yang C, Yan J, Cui D, Peng Y, He Q, Gao Y. The alteration of brain interstitial fluid drainage with myelination development. Aging and disease. 2021 Oct;12(7):1729. 
  24. Zhao G, Han H*, Wang W*, Jia K. Propofol rather than Isoflurane Accelerates the Interstitial Fluid Drainage in the Deep Rat Brain. Int J Med Sci. 2021 Jan 1;18(3):652-659.  
  25. Yao D, He Q, Bai S, Zhao H, Yang J, Cui D, Yu Y, Fei X, Mei Y, Cheng Y, Yan S, Huang N, Di Y, Cai X, Wang R, Gao Y, Cheng F, Zhao S, Yang X, Cai X*, Han H*, Lyu J*, Tong Z*. Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading. Commun Biol. 2021 Aug 19;4(1):933.
  26. Zhao G, Han H*, Yang J*, Sun M, Cui D, Li Y, Gao Y, Zou J. Brain interstitial fluid drainage and extracellular space affected by inhalational isoflurane: in comparison with intravenous sedative dexmedetomidine and pentobarbital sodium. Sci China Life Sci. 2020 Sep;63(9):1363-1379.
  27. Li Y, Han H*, Shi K, Cui D, Yang J, Alberts IL, Yuan L, Zhao G, Wang R, Cai X, Teng Z. The mechanism of downregulated interstitial fluid drainage following neuronal excitation. Aging and disease. 2020 Dec;11(6):1407.