<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yang, Y.</style></author><author><style face="normal" font="default" size="100%">Gao, X.</style></author><author><style face="normal" font="default" size="100%">Just, A. C.</style></author><author><style face="normal" font="default" size="100%">Colicino, E.</style></author><author><style face="normal" font="default" size="100%">C. Wang</style></author><author><style face="normal" font="default" size="100%">Coull, B. A.</style></author><author><style face="normal" font="default" size="100%">Hou, L.</style></author><author><style face="normal" font="default" size="100%">Zheng, Y.</style></author><author><style face="normal" font="default" size="100%">Vokonas, P.</style></author><author><style face="normal" font="default" size="100%">Schwartz, J.</style></author><author><style face="normal" font="default" size="100%">Baccarelli, A. A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Smoking-Related DNA Methylation is Associated with DNA Methylation Phenotypic Age Acceleration: The Veterans Affairs Normative Aging Study</style></title><secondary-title><style face="normal" font="default" size="100%">Int J Environ Res Public Health</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">80 and over Aging/*genetics Biomarkers CpG Islands *DNA Methylation Humans Longitudinal Studies Male Massachusetts Middle Aged Phenotype Self Report Tobacco Smoking/*genetics *Veterans *DNA methylation phenotypic age *aging acceleration *aging biomarker</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged Aged</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/31277270</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">13</style></number><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">2356</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">DNA methylation may play a critical role in aging and age-related diseases. DNA methylation phenotypic age (DNAmPhenoAge) is a new aging biomarker and predictor of chronic disease risk. While smoking is a strong risk factor for chronic diseases and influences methylation, its influence on DNAmPhenoAge is unknown. We investigated associations of self-reported and epigenetic smoking indicators with DNAmPhenoAge acceleration in a longitudinal aging study in eastern Massachusetts. DNA methylation was measured in whole blood samples from multiple visits for 692 male participants in the Veterans Affairs Normative Aging Study during 1999-2013. Acceleration was defined using residuals from linear regression of the DNAmPhenoAge on the chronological age. Cumulative smoking (pack-years) was significantly associated with DNAmPhenoAge acceleration, whereas self-reported smoking status was not. We observed significant validated associations between smoking-related loci and DNAmPhenoAge acceleration for 52 CpG sites, where 18 were hypomethylated and 34 were hypermethylated, mapped to 16 genes. The AHRR gene had the most loci (N = 8) among the 16 genes. We generated a smoking aging index based on these 52 loci, which showed positive significant associations with DNAmPhenoAge acceleration. These epigenetic biomarkers may help to predict age-related risks driven by smoking.</style></abstract><work-type><style face="normal" font="default" size="100%">Journal Article</style></work-type><notes><style face="normal" font="default" size="100%">Yang, Yang Gao, Xu Just, Allan C Colicino, Elena Wang, Cuicui Coull, Brent A Hou, Lifang Zheng, Yinan Vokonas, Pantel Schwartz, Joel Baccarelli, Andrea A eng Switzerland Int J Environ Res Public Health. 2019 Jul 3;16(13). pii: ijerph16132356. doi: 10.3390/ijerph16132356.</style></notes></record></records></xml>