<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Schottker, B.</style></author><author><style face="normal" font="default" size="100%">Hagen, L.</style></author><author><style face="normal" font="default" size="100%">Y. Zhang</style></author><author><style face="normal" font="default" size="100%">Gao, X.</style></author><author><style face="normal" font="default" size="100%">Holleczek, B.</style></author><author><style face="normal" font="default" size="100%">Gao, X.</style></author><author><style face="normal" font="default" size="100%">Brenner, H.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels</style></title><secondary-title><style face="normal" font="default" size="100%">J Gerontol A Biol Sci Med Sci</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aged Aging/*blood Biomarkers/blood Cause of Death/trends Dinoprost/*analogs &amp; derivatives/blood Epigenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic/*genetics Epigenomics/*methods Female Follow-Up Studies Germany/epidemiology Humans Male Middle Aged Retrospective Studies Telomere/*metabolism Vitamin D/*analogs &amp; derivatives/blood Vitamin D Deficiency/*blood/genetics/mortality</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/30371905</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">74</style></volume><pages><style face="normal" font="default" size="100%">121-128</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Background: A strong association of serum 25-hydroxyvitamin-D levels (25(OH)D) with all-cause mortality has been shown previously and 25(OH)D could be a useful aging marker. Methods: The analysis was performed in a population-based, cohort study from Germany with 9,940 participants, aged 50-74 years at baseline. A general linear model was used to assess associations of 25(OH)D levels with chronological age and the aging markers leukocyte telomere length (LTL), epigenetic age acceleration, and 8-isoprostane levels. A multivariate Cox regression model was applied to explore the independent and combined associations of these biomarkers with all-cause mortality (2,204 deaths occurred during a median follow-up of 14.3 years). Results: On average, study participants lost 2.9 nmol/L 25(OH)D each 10 years of age. Increasing 25(OH)D levels were significantly associated with decreasing levels of 8-isoprostane levels but neither with LTL nor epigenetic age acceleration. The association of 25(OH)D quartiles with mortality was almost unchanged after adjusting for all aging markers (1.6-fold increased mortality in bottom quartile compared with top quartile). All aging markers were independent mortality predictors and subjects with unfavorable values for 4, 3, 2, and 1 aging marker(s) had 4.3-, 2.9-, 2.2, and 1.4-fold increased mortality, respectively. Conclusions: The 25(OH)D level can be regarded as an aging marker because it is linearly associated with age and an independent mortality predictor. Mechanisms linking vitamin D to healthy aging are unique and can neither be fully explained by aging of the epigenome, loss of telomeres, or antioxidative effects of vitamin D metabolites.</style></abstract><work-type><style face="normal" font="default" size="100%">Journal Article</style></work-type><notes><style face="normal" font="default" size="100%">Schottker, Ben Hagen, Leonie Zhang, Yan Gao, Xin Holleczek, Bernd Gao, Xu Brenner, Hermann eng Multicenter Study Research Support, Non-U.S. Gov&amp;#039;t J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):121-128. doi: 10.1093/gerona/gly253.</style></notes></record></records></xml>