<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gao, X.</style></author><author><style face="normal" font="default" size="100%">Y. Zhang</style></author><author><style face="normal" font="default" size="100%">Schottker, B.</style></author><author><style face="normal" font="default" size="100%">Brenner, H.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vitamin D status and epigenetic-based mortality risk score: strong independent and joint prediction of all-cause mortality in a population-based cohort study</style></title><secondary-title><style face="normal" font="default" size="100%">Clin Epigenetics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aged Cohort Studies *DNA Methylation Epigenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Female Germany Humans Male Middle Aged *Mortality Risk Factors Vitamin D/*analogs &amp; derivatives/blood/*metabolism *Vitamin D Deficiency *All-cause mortality *Epigenetic epidemiology *Epigenetic mortality risk score *Precision medicine *Vitamin D</style></keyword><keyword><style  face="normal" font="default" size="100%">Germany. Written informed consent was obtained from all participants.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/29977410</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">84</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Background: Vitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic &amp;quot;mortality risk score&amp;quot; (MS) based on whole blood DNA methylation at the 10 most prominent mortality-related cytosine-phosphate-guanine (CpG) sites has also been found to be highly related to all-cause mortality. This study aimed to explore whether vitamin D status, defined by serum 25-hydroxyvitamin D [25(OH)D] concentrations, is associated with the MS and to what extent both indicators are individually and jointly capable of predicting all-cause mortality in a general population sample of older adults. Results: The MS was derived from the blood DNA methylation profiles measured by Illumina Human Methylation 450K Beadchip, and serum 25(OH)D concentration was measured among 1467 participants aged 50-75 of the German ESTHER cohort study. There was no association between vitamin D status and the MS at baseline, but both metrics were prominently and independently associated with all-cause mortality during a median follow-up of 15.2 years. The combination of both indicators showed the potential to be a particularly strong prognostic index for all-cause mortality. Participants with vitamin D deficiency (&amp;lt; 30 nmol/L) and high MS (&amp;gt; 5 CpG sites with aberrant methylation) had almost sixfold mortality (hazard ratio 5.79, 95% CI 3.06-10.94) compared with participants with sufficient vitamin D (&amp;gt;/= 50 nmol/L) and a low MS (0-1 CpG site with aberrant methylation). Conclusions: This study suggests that vitamin D and the MS are strong independent predictors of all-cause mortality in older adults.</style></abstract><work-type><style face="normal" font="default" size="100%">Journal Article</style></work-type><notes><style face="normal" font="default" size="100%">Gao, Xu Zhang, Yan Schottker, Ben Brenner, Hermann eng Research Support, Non-U.S. Gov&amp;#039;t Germany Clin Epigenetics. 2018 Jun 20;10:84. doi: 10.1186/s13148-018-0515-y. eCollection 2018.</style></notes></record></records></xml>