<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gao, X.</style></author><author><style face="normal" font="default" size="100%">Gao, X.</style></author><author><style face="normal" font="default" size="100%">Y. Zhang</style></author><author><style face="normal" font="default" size="100%">Holleczek, B.</style></author><author><style face="normal" font="default" size="100%">Schottker, B.</style></author><author><style face="normal" font="default" size="100%">Brenner, H.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people</style></title><secondary-title><style face="normal" font="default" size="100%">Eur J Epidemiol</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aged Cause of Death Cohort Studies *Epigenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Female Germany/epidemiology Humans Male Middle Aged *Mortality *Oxidative Stress Risk Assessment Aging All-cause mortality DNA methylation Epigenetic epidemiology Mortality risk score Oxidative stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/30771035</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">5</style></number><volume><style face="normal" font="default" size="100%">34</style></volume><pages><style face="normal" font="default" size="100%">451-462</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Oxidative stress (OS) has been found to be related to accelerated aging and many aging-related health outcomes. Recently, an epigenetic &amp;quot;mortality risk score&amp;quot; (MS) based on whole blood DNA methylation at 10 mortality-related CpG sites has been demonstrated to be associated with all-cause mortality. This study aimed to address the association between OS and MS, and to assess and compare their performance in the prediction of all-cause mortality. For 1448 participants aged 50-75 of the German ESTHER cohort study, the MS was derived from the DNA methylation profiles measured by Illumina HumanMethylation450K Beadchip and the levels of two urinary OS markers, 8-isoprostane (8-iso) and oxidized guanine/guanosine [including 8-hydroxy-2&amp;#039;-deoxyguanosine (8-oxo)], were measured by ELISA kits. Associations between OS markers and the MS were evaluated by linear and ordinal logistic regression models, and their associations with all-cause mortality were examined by Cox regression models. Both OS markers were associated with the MS at baseline. The 8-iso levels and MS, but not 8-oxo levels, were associated with all-cause mortality during a median follow-up of 15.1 years. Fully-adjusted hazard ratios (95% CI) were 1.56 (1.13-2.16) for the 4th quartile of 8-iso levels compared with the 1st, 1.71 (1.27-2.29) and 2.92 (2.03-4.18) for the moderate and high MS defined by 2-5 and &amp;gt; 5 CpG sites with aberrant methylation compared with a MS of 0-1, respectively. After controlling for 8-iso levels, the hazard ratios of MS remained essentially unchanged while the association of 8-iso levels with mortality was attenuated. This study demonstrates that OS is highly associated with the epigenetic MS, and the latter at the same time has a higher predictive value for all-cause mortality.</style></abstract><work-type><style face="normal" font="default" size="100%">Journal Article</style></work-type><notes><style face="normal" font="default" size="100%">Gao, Xu Gao, Xin Zhang, Yan Holleczek, Bernd Schottker, Ben Brenner, Hermann eng Netherlands Eur J Epidemiol. 2019 May;34(5):451-462. doi: 10.1007/s10654-019-00493-7. Epub 2019 Feb 15.</style></notes></record></records></xml>