<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Liu, Qisijing</style></author><author><style face="normal" font="default" size="100%">Hongyu Li</style></author><author><style face="normal" font="default" size="100%">Guo, Liqiong</style></author><author><style face="normal" font="default" size="100%">Chen, Qiao</style></author><author><style face="normal" font="default" size="100%">Gao, Xu</style></author><author><style face="normal" font="default" size="100%">Li, Peng-hui</style></author><author><style face="normal" font="default" size="100%">Tang, Naijun</style></author><author><style face="normal" font="default" size="100%">Guo, Xinbiao</style></author><author><style face="normal" font="default" size="100%">Deng, Furong</style></author><author><style face="normal" font="default" size="100%">Wu, Shaowei</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Short-term Personal Exposure to Air Pollution on Platelet Mitochondrial DNA Methylation Levels and the Potential Mitigation by L-arginine Supplementation</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Hazardous Materials</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">air pollution L-arginine</style></keyword><keyword><style  face="normal" font="default" size="100%">methylation mitochondrial DNA platelet</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.sciencedirect.com/science/article/pii/S0304389421009274</style></url></web-urls></urls><pages><style face="normal" font="default" size="100%">125963</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The potential effect of short-term exposure to air pollution on mitochondrial DNA (mtDNA) methylation remains to be explored. This study adopted an experimental exposure protocol nested with an intervention study on L-arginine (L-Arg) supplementation. Participants walked along a traffic road for 2h in the last day of a 14-day intervention to investigate the effects of short-term personal exposure to air pollution on platelet mtDNA methylation and the possible modifying effects of L-Arg supplementation. Results showed that short-term personal exposure to air pollutants was associated with hypomethylation in platelet mtDNA. Specifically, 2-h fine particulate matter (PM2.5) exposure during the outdoor walk was significantly associated with hypomethylation in mt12sRNA and ATP6; 24-h black carbon (BC) exposure from the start of the walk till next morning and 2-h NO2 exposure was significantly associated with hypomethylation in ATP8; and 24-h PM2.5 exposure, 2-h and 24-h BC exposure were significantly associated with hypomethylation in D-loop. Supplementation with L-Arg could mitigate the air pollution effects on methylation in ATP8 and D-loop. These findings suggest that platelet mtDNA methylation may be sensitive effect biomarker for short-term exposure to air pollution and may help deepen the understanding of the epigenetic mechanisms of adverse cardiovascular effects of air pollution.</style></abstract><work-type><style face="normal" font="default" size="100%">Journal Article</style></work-type></record></records></xml>