@article {28815,
	title = {Meta-analyses identify DNA methylation associated with kidney function and damage},
	journal = {Nat CommunNat Commun},
	volume = {12},
	number = {1},
	year = {2021},
	note = {Schlosser, PascalTin, AdrienneMatias-Garcia, Pamela RThio, Chris H LJoehanes, RobyLiu, HongboWeihs, AntoineYu, ZhiHoppmann, AnselmGrundner-Culemann, FranziskaMin, Josine LAdeyemo, Adebowale AAgyemang, CharlesArnlov, JohanAziz, Nasir ABaccarelli, AndreaBochud, MurielleBrenner, HermannBreteler, Monique M BCarmeli, CristianChaker, LayalChambers, John CCole, Shelley ACoresh, JosefCorre, TanguyCorrea, AdolfoCox, Simon Rde Klein, NiekDelgado, Graciela EDomingo-Relloso, ArceEckardt, Kai-UweEkici, Arif BEndlich, KarlhansEvans, Kathryn LFloyd, James SFornage, MyriamFranke, LudeFraszczyk, ElizaGao, XuGao, XinGhanbari, MohsenGhasemi, SaharGieger, ChristianGreenland, PhilipGrove, Megan LHarris, Sarah EHemani, GibranHenneman, PeterHerder, ChristianHorvath, SteveHou, LifangHurme, Mikko AHwang, Shih-JenJarvelin, Marjo-RiittaKardia, Sharon L RKasela, SilvaKleber, Marcus EKoenig, WolfgangKooner, Jaspal SKramer, HollyKronenberg, FlorianKuhnel, BrigitteLehtimaki, TerhoLind, LarsLiu, DanLiu, YongmeiLloyd-Jones, Donald MLohman, KurtLorkowski, StefanLu, Ake TMarioni, Riccardo EMarz, WinfriedMcCartney, Daniel LMeeks, Karlijn A CMilani, LiliMishra, Pashupati PNauck, MatthiasNavas-Acien, AnaNowak, ChristophPeters, AnnetteProkisch, HolgerPsaty, Bruce MRaitakari, Olli TRatliff, Scott MReiner, Alex PRosas, Sylvia ESchottker, BenSchwartz, JoelSedaghat, SanazSmith, Jennifer ASotoodehnia, NonaStocker, Hannah RStringhini, SilviaSundstrom, JohanSwenson, Brenton RTellez-Plaza, Mariavan Meurs, Joyce B Jvan Vliet-Ostaptchouk, Jana VVenema, AndreaVerweij, NiekWalker, Rosie MWielscher, MatthiasWinkelmann, JulianeWolffenbuttel, Bruce H RZhao, WeiZheng, YinanLoh, MarieSnieder, HaroldLevy, DanielWaldenberger, MelanieSusztak, KatalinKottgen, AnnaTeumer, Alexandereng192904750/Deutsche Forschungsgemeinschaft (German Research Foundation)England2021/12/11Nat Commun. 2021 Dec 9;12(1):7174. doi: 10.1038/s41467-021-27234-3.},
	month = {Dec 9},
	pages = {7174},
	edition = {20211209},
	abstract = {Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.},
	isbn = {2041-1723 (Electronic)2041-1723 (Linking)},
	author = {Schlosser, P. and Tin, A. and Matias-Garcia, P. R. and Thio, C. H. L. and Joehanes, R. and Liu, H. and Weihs, A. and Yu, Z. and Hoppmann, A. and Grundner-Culemann, F. and Min, J. L. and Adeyemo, A. A. and Agyemang, C. and Arnlov, J. and Aziz, N. A. and Baccarelli, A. and Bochud, M. and Brenner, H. and Breteler, M. M. B. and Carmeli, C. and Chaker, L. and Chambers, J. C. and Cole, S. A. and Coresh, J. and Corre, T. and Correa, A. and Cox, S. R. and de Klein, N. and Delgado, G. E. and Domingo-Relloso, A. and Eckardt, K. U. and Ekici, A. B. and Endlich, K. and Evans, K. L. and Floyd, J. S. and Fornage, M. and Franke, L. and Fraszczyk, E. and Gao, X. and Gao, X. and Ghanbari, M. and Ghasemi, S. and Gieger, C. and Greenland, P. and Grove, M. L. and Harris, S. E. and Hemani, G. and Henneman, P. and Herder, C. and Horvath, S. and Hou, L. and Hurme, M. A. and S.J. Hwang and Jarvelin, M. R. and Kardia, S. L. R. and Kasela, S. and Kleber, M. E. and Koenig, W. and Kooner, J. S. and Kramer, H. and Kronenberg, F. and Kuhnel, B. and Lehtimaki, T. and Lind, L. and Liu, D. and Y. Liu and Lloyd-Jones, D. M. and Lohman, K. and Lorkowski, S. and Lu, A. T. and Marioni, R. E. and Marz, W. and McCartney, D. L. and Meeks, K. A. C. and Milani, L. and Mishra, P. P. and Nauck, M. and Navas-Acien, A. and Nowak, C. and Peters, A. and Prokisch, H. and Psaty, B. M. and Raitakari, O. T. and Ratliff, S. M. and Reiner, A. P. and Rosas, S. E. and Schottker, B. and Schwartz, J. and Sedaghat, S. and Smith, J. A. and Sotoodehnia, N. and Stocker, H. R. and Stringhini, S. and Sundstrom, J. and Swenson, B. R. and Tellez-Plaza, M. and van Meurs, J. B. J. and Van Vliet-Ostaptchouk, J. V. and Venema, A. and Verweij, N. and Walker, R. M. and Wielscher, M. and Winkelmann, J. and Wolffenbuttel, B. H. R. and Zhao, W. and Zheng, Y. and Estonian Biobank Research, Team and Genetics of, D. N. A. Methylation Consortium and Loh, M. and Snieder, H. and Levy, D. and Waldenberger, M. and Susztak, K. and Kottgen, A. and Teumer, A.}
}
