@article {27257,
	title = {Effects of Short-term Personal Exposure to Air Pollution on Platelet Mitochondrial DNA Methylation Levels and the Potential Mitigation by L-arginine Supplementation},
	journal = {Journal of Hazardous Materials},
	year = {2021},
	pages = {125963},
	type = {Journal Article},
	abstract = {The potential effect of short-term exposure to air pollution on mitochondrial DNA (mtDNA) methylation remains to be explored. This study adopted an experimental exposure protocol nested with an intervention study on L-arginine (L-Arg) supplementation. Participants walked along a traffic road for 2h in the last day of a 14-day intervention to investigate the effects of short-term personal exposure to air pollution on platelet mtDNA methylation and the possible modifying effects of L-Arg supplementation. Results showed that short-term personal exposure to air pollutants was associated with hypomethylation in platelet mtDNA. Specifically, 2-h fine particulate matter (PM2.5) exposure during the outdoor walk was significantly associated with hypomethylation in mt12sRNA and ATP6; 24-h black carbon (BC) exposure from the start of the walk till next morning and 2-h NO2 exposure was significantly associated with hypomethylation in ATP8; and 24-h PM2.5 exposure, 2-h and 24-h BC exposure were significantly associated with hypomethylation in D-loop. Supplementation with L-Arg could mitigate the air pollution effects on methylation in ATP8 and D-loop. These findings suggest that platelet mtDNA methylation may be sensitive effect biomarker for short-term exposure to air pollution and may help deepen the understanding of the epigenetic mechanisms of adverse cardiovascular effects of air pollution.},
	keywords = {air pollution L-arginine, methylation mitochondrial DNA platelet},
	issn = {03043894},
	doi = {10.1016/j.jhazmat.2021.125963},
	url = {https://www.sciencedirect.com/science/article/pii/S0304389421009274},
	author = {Liu, Qisijing and Hongyu Li and Guo, Liqiong and Chen, Qiao and Gao, Xu and Li, Peng-hui and Tang, Naijun and Guo, Xinbiao and Deng, Furong and Wu, Shaowei}
}
