@article {35411,
	title = {Highly enantioselective biomimetic intramolecular dehydration: kinetic resolution of β-hydroxy ketones catalyzed by β-turn tetrapeptides},
	journal = {Tetrahedron LettersTetrahedron Letters},
	volume = {54},
	number = {22},
	year = {2013},
	month = {2013/05/29/},
	pages = {2828-2832},
	abstract = {Racemic β-hydroxy ketones were kinetically resoluted into the enantiopure isomers and (E)-α,β-unsaturated ketones using catalytic asymmetric intramolecular dehydration for the first time. Synthetic tetrapeptides were used to imitate fatty acid dehydratases to efficiently discriminate racemic β-hydroxy ketones, enantioselectively catalyze the intramolecular dehydration, and result in highly enantioenriched β-hydroxy and (E)-α,β-unsaturated ketones in the environmentally benign process. Mechanistically, the high discrimination of the racemic substrates and successive enantioselective dehydration are highly dependent on the cooperative catalysis of the NH2 and COOH groups of the peptide.},
	keywords = {asymmetric catalysis, Biomimetic course, Dehydration, Kinetic resolution, Peptide},
	isbn = {0040-4039},
	author = {Du, Zhi-Xue and Li-Yuan Zhang and Fan, Xin-Yuan and Wu, Feng-Chun and Da, Chao-Shan}
}
