@article {35410,
	title = {A site isolation-enabled organocatalytic approach to enantiopure γ-amino alcohol drugs},
	journal = {TetrahedronTetrahedron},
	volume = {74},
	number = {29},
	year = {2018},
	month = {2018/07/19/},
	pages = {3943-3946},
	abstract = {Solid support-enabled site isolation has previously allowed to use paraldehyde as an acetaldehyde surrogate in aldol reactions. However, only electron-poor aldehydes were tolerated by the system. Herein, we show that the temporary conversion of benzaldehyde into η6-benzaldehyde Cr(CO)3 circumvents this limitation. Asymmetric synthesis of (R)-Phenoperidine, as well as formal syntheses of (R)-Fluoxetine and (R)-Atomoxetine, illustrate the benefits of this strategy.},
	keywords = {-Arene chromium complexes, Phenoperidine, site isolation, Solid-supported catalysts, γ-Amino alcohol drugs},
	isbn = {0040-4020},
	author = {Wang, Shoulei and Rodr{\'\i}guez-Escrich, Carles and Xinyuan Fan and Peric{\`a}s, Miquel A.}
}
