@article {35404,
	title = {Highly Catalytic Asymmetric Addition of Deactivated Alkyl Grignard Reagents to Aldehydes},
	journal = {Organic LettersOrganic LettersOrganic Letters},
	volume = {11},
	number = {24},
	year = {2009},
	note = {528QOTimes Cited:29Cited References Count:53},
	month = {Dec 17},
	pages = {5578-5581},
	abstract = {Generally used and highly reactive RMgBr reagents were effectively deactivated by bis[2-(N,N-dimethylamino)ethyl] ether and then were employed in the highly enantioselective addition of Grignard reagents to aldehydes. The reaction was catalyzed by the complex of commercially available (S)-BINOL and Ti(O\&$\#$039;Pr-)(4) under mild conditions. Compared with the other observed Grignard reagents, alkyl Grignard reagents showed higher enantioselectivity and they achieved \&gt;99\% ee.},
	keywords = {1,2-addition, amino-alcohols, aryl ketones, chiral ligands, complexes, enantioselective addition, prochiral aldehydes, titanium, transfer hydrogenation, zinc},
	isbn = {1523-7060},
	author = {Da, C. S. and Wang, J. R. and Yin, X. G. and Fan, X. Y. and Y. Liu and Yu, S. L.}
}
