@article {35403,
	title = {Visible light-mediated cross-coupling of electrophiles: synthesis of α-amino amides from isocyanates and ketimines},
	journal = {Organic Chemistry FrontiersOrganic Chemistry Frontiers},
	volume = {8},
	number = {6},
	year = {2021},
	pages = {1227-1232},
	publisher = {The Royal Society of Chemistry},
	type = {10.1039/D0QO01620A},
	abstract = {A catalytic system to synthesize α-amino amides from isocyanates and ketimines has been developed using visible light iridium photoredox catalysis via umpolung reactivity of ketimines. Cross-couplings between diverse ketimine and isocyanate substrates have been evaluated, affording the desired α-amino amide products in good yields. In addition, a metal-free catalytic system using perylene and N,N-diisopropylethylamine has been developed. Finally, single-step synthesis of the psychoactive drug benzodiazepine-2-one analogue from one of the coupling products has been achieved, indicating the great application potential of the synthetic method developed herein.},
	author = {Zhu, Junli and Dai, Cancan and Ma, Mengyue and Yue, Yanni and Xinyuan Fan*}
}
