@article {35391,
	title = {Calcium carbonate as heterogeneous support for recyclable organocatalysts},
	journal = {Journal of CatalysisJournal of Catalysis},
	volume = {393},
	year = {2021},
	month = {2021/01/01/},
	pages = {107-115},
	abstract = {The controlled synthesis of calcium carbonate particles surface-functionalized with azido groups and its subsequent copper-catalyzed alkyne-azide cycloaddition (CuAAC) reactions with organocatalysts bearing alkyne anchors allowed the preparation of novel catalytic materials. A calcium carbonate-supported α,α-diarylprolinol silyl ether prepared in this manner catalyzes Michael addition of aldehydes to trans-β-nitrostyrenes with very high diastereo- and enantioselectivity. The immobilized catalyst can be recovered by simple decantation and reused. In addition, this heterogeneous catalytic system can also be adapted to continuous-flow operation, affording a five-fold productivity increase in comparison with the batch process.},
	keywords = {asymmetric catalysis, Calcium carbonate, Catalyst recycling, Click chemistry, Continuous flow processes, Solid-supported catalysis, Surface functionalization},
	isbn = {0021-9517},
	author = {Lizandara-Pueyo, Carlos* and Xinyuan Fan* and Ayats, Carles and Peric{\`a}s, Miquel A.}
}
