@article {35386,
	title = {Deuteration Degree-Controllable Methylation via a Cascade Assembly Strategy using Methylamine-Water as Methyl Source},
	journal = {Chemistry {\textendash} A European Journal},
	volume = {29},
	number = {45},
	year = {2023},
	month = {2023/08/10},
	pages = {e202301458},
	publisher = {John Wiley \&amp;amp; Sons, Ltd},
	abstract = {Abstract We present a novel and effective photocatalytic method for the methylation of ?-diketones with controllable degrees of deuterium incorporation via development of new methyl sources. By utilizing a methylamine-water system as the methyl precursor and a cascade assembly strategy for deuteration degree control, we synthesized methylated compounds with varying degrees of deuterium incorporation, showcasing the versatility of this approach. We examined a range of ?-diketone substrates and synthesized key intermediates for drug and bioactive compounds with varying degrees of deuterium incorporation, ranging from 0 to 3. We also investigated and discussed the postulated reaction pathway. This work demonstrates the utility of readily available reagents, methylamines and water, as a new methyl source, and provides a simple and efficient strategy for the synthesis of degree-controllable deuterium-labelled compounds.},
	keywords = {D2O, deuteration, methylation, Photocatalysis, TMEDA},
	isbn = {0947-6539},
	author = {Guo, Fuhu and Shan, Shiquan and Gong, Xu and Dai, Cancan and Quan, Zhengjun* and Cheng, Xiamin* and Xinyuan Fan*}
}
