@article {35385,
	title = {Highly Enantioselective Cross-Aldol Reactions of Acetaldehyde Mediated by a Dual Catalytic System Operating under Site Isolation},
	journal = {Chemistry {\textendash} A European Journal},
	volume = {20},
	number = {41},
	year = {2014},
	month = {2014/10/06},
	pages = {13089-13093},
	publisher = {John Wiley \&amp; Sons, Ltd},
	abstract = {Abstract Polystyrene-supported (PS) diarylprolinol catalysts 1?a (Ar=phenyl) and 1?b (Ar=3,5-bis(trifluoromethyl)phenyl) have been developed. Operating under site-isolation conditions, PS-1?a/1?b worked compatibly with PS-bound sulfonic acid catalyst 2 to promote deoligomerization of paraldehyde and subsequent cross-aldol reactions of the resulting acetaldehyde in one pot, affording aldol products in high yields with excellent enantioselectivities. The effect of water on the performance of the catalytic system has been studied and its optimal amount (0.5?equiv) has been determined. The dual catalytic system (1/2) allows repeated recycling and reuse (10 cycles). The potential of this methodology is demonstrated by a two-step synthesis of a phenoperidine analogue (68?\% overall yield; 98?\%?ee) and by the preparation of highly enantioenriched 1,3-diols 4 and 3-methylamino-1-arylpropanols 5, key intermediates in the synthesis of a variety of druglike structures.},
	keywords = {acetaldehyde, cross-aldol, Recycling, site-isolation, wolf and lamb},
	isbn = {0947-6539},
	author = {Xinyuan Fan and Rodr{\'\i}guez-Escrich, Carles and Wang, Shoulei and Sayalero, Sonia and Peric{\`a}s, Miquel A.}
}
