@article {35375,
	title = {Asymmetric alpha-Amination of Aldehydes Catalyzed by PS-Diphenylprolinol Silyl Ethers: Remediation of Catalyst Deactivation for Continuous Flow Operation},
	journal = {Advanced Synthesis \&amp; CatalysisAdvanced Synthesis \&amp; Catalysis},
	volume = {354},
	number = {16},
	year = {2012},
	note = {034NBTimes Cited:35Cited References Count:54},
	month = {Nov},
	pages = {2971-2976},
	abstract = {Polystyrene (PS)-supported diphenylprolinol silyl ethers have been developed as highly active catalysts for the enantioselective a-amination of aldehydes. Understanding the mechanism of catalyst deactivation has led to the development of reaction conditions notably extending catalyst life in repeated recycling (10 cycles; accumulated TON of 480) and has allowed the implementation of a continuous flow alpha-amination process (6 min residence time, 8 h operation).},
	keywords = {amino-acids, asymmetric alpha-amination, azodicarboxylates, batch, carbonyl-compounds, continuous flow operation, diphenylprolinol silyl ethers, functionalization, hydrazination, hydroformylation, ionic liquids, Ketones, organocatalysis, solid-supported organocatalyst, supported catalysts},
	isbn = {1615-4150},
	author = {Fan, X. Y. and Sayalero, S. and Pericas, M. A.}
}
