<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dou, Yanmei</style></author><author><style face="normal" font="default" size="100%">Yang, Xiaoxu</style></author><author><style face="normal" font="default" size="100%">Ziyi Li</style></author><author><style face="normal" font="default" size="100%">Wang, Sheng</style></author><author><style face="normal" font="default" size="100%">Zhang, Zheng</style></author><author><style face="normal" font="default" size="100%">Ye, Adam Yongxin</style></author><author><style face="normal" font="default" size="100%">Yan, Linlin</style></author><author><style face="normal" font="default" size="100%">Yang, Changhong</style></author><author><style face="normal" font="default" size="100%">Qixi Wu</style></author><author><style face="normal" font="default" size="100%">Li, Jiarui</style></author><author><style face="normal" font="default" size="100%">others</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Postzygotic single-nucleotide mosaicisms contribute to the etiology of autism spectrum disorder and autistic traits and the origin of mutations</style></title><secondary-title><style face="normal" font="default" size="100%">Human mutation</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.23255</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">8</style></number><volume><style face="normal" font="default" size="100%">38</style></volume><pages><style face="normal" font="default" size="100%">1002–1013</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The roles and characteristics of postzygotic single‐nucleotide mosaicisms (pSNMs) in autism spectrum disorders (ASDs) remain unclear. In this study of the whole exomes of 2,361 families in the Simons Simplex Collection, we identified 1,248 putative pSNMs in children and 285 &lt;em&gt;de&amp;nbsp;novo&lt;/em&gt; SNPs in children with detectable parental mosaicism. Ultra‐deep amplicon resequencing suggested a validation rate of 51%. Analyses of validated pSNMs revealed that missense/loss‐of‐function (LoF) pSNMs with a high mutant allele fraction (MAF≥ 0.2) contributed to ASD diagnoses (&lt;em&gt;P&lt;/em&gt; = 0.022, odds ratio [OR] = 5.25), whereas missense/LoF pSNMs with a low MAF (MAF&amp;lt;0.2) contributed to autistic traits in male non‐ASD siblings (&lt;em&gt;P&lt;/em&gt; = 0.033). LoF pSNMs in parents were less likely to be transmitted to offspring than neutral pSNMs (&lt;em&gt;P&lt;/em&gt; = 0.037), and missense/LoF pSNMs in parents with a low MAF were transmitted more to probands than to siblings (&lt;em&gt;P&lt;/em&gt; = 0.016, OR = 1.45). We estimated that pSNMs in probands or &lt;em&gt;de&amp;nbsp;novo&lt;/em&gt; mutations inherited from parental pSNMs increased the risk of ASD by approximately 6%. Adding pSNMs into the transmission and &lt;em&gt;de&amp;nbsp;novo&lt;/em&gt; association test model revealed 13 new ASD risk genes. These results expand the existing repertoire of genes involved in ASD and shed new light on the contribution of genomic mosaicisms to ASD diagnoses and autistic traits.&lt;/p&gt;</style></abstract></record></records></xml>