<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">X. Li</style></author><author><style face="normal" font="default" size="100%">T. Wang</style></author><author><style face="normal" font="default" size="100%">Zhao, M.</style></author><author><style face="normal" font="default" size="100%">Huang, T.</style></author><author><style face="normal" font="default" size="100%">Sun, D.</style></author><author><style face="normal" font="default" size="100%">Han, L.</style></author><author><style face="normal" font="default" size="100%">Nisa, H.</style></author><author><style face="normal" font="default" size="100%">Shang, X.</style></author><author><style face="normal" font="default" size="100%">Heianza, Y.</style></author><author><style face="normal" font="default" size="100%">Qi, L.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">DNA methylation variant, B-vitamins intake and longitudinal change in body mass index</style></title><secondary-title><style face="normal" font="default" size="100%">Int J Obes (Lond)Int J Obes (Lond)</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 17</style></date></pub-dates></dates><edition><style face="normal" font="default" size="100%">2018/05/20</style></edition><isbn><style face="normal" font="default" size="100%">1476-5497 (Electronic)0307-0565 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND: Growing evidence has implicated DNA methylation (DNAm) in the regulation of body adiposity; a recent epigenome-wide association study (EWAS) identified a genetic variant determining DNAm at the SREBF1 gene that affected body mass index (BMI). OBJECTIVE: In the present study, we tested interactions between DNAm variant rs752579 and methylation metabolism-related B-vitamins (folate, vitamin B2, vitamin B6, and vitamin B12) on longitudinal change in BMI in the Women&amp;#039;s Health Initiative Memory Study (WHIMS). DESIGN: A total of 5687 white women aged 65-79 from WHIMS with genotyping data on SNP rs752579 were included in the analysis. B-vitamins intakes were estimated by a self-report semi-quantitative food frequency questionnaire. BMI was measured at baseline and 6-year follow-up. RESULT: We found significant interactions between the SREBF1 rs752579 genotype and intake of food source B-vitamins on 6-year change in BMI (p interaction &amp;lt;0.01 for all). BMI changes (kg/m(2)) per DNAm-increasing (C) allele were -0.29, 0.06, and 0.11 within subgroups of increasing tertiles of food source folate intake; and the corresponding BMI changes (kg/m(2)) were -0.25, -0.01, and 0.15 for vitamin B2 intake; -0.17, -0.16, and 0.21 for vitamin B6 intake; and -0.12, -0.23, and 0.26 for vitamin B12 intake, respectively. Similar gene-diet interaction patterns were observed on the change in body weight. CONCLUSIONS: Our data suggest that habitual intake of food source B-vitamins may modify the effect of DNAm-related variant on long-term adiposity change.</style></abstract><accession-num><style face="normal" font="default" size="100%">29777237</style></accession-num><notes><style face="normal" font="default" size="100%">Li, XiangWang, TiangeZhao, MinHuang, TaoSun, DianjianyiHan, LiyuanNisa, HoirunShang, XiaoyunHeianza, YorikoQi, LuEngland2005Int J Obes (Lond). 2018 May 17. pii: 10.1038/s41366-018-0106-1. doi: 10.1038/s41366-018-0106-1.</style></notes><auth-address><style face="normal" font="default" size="100%">Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.Epidemiology Domain, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.Department of Public Health, Faculty of Medicine and Health Sciences, State Islamic University, Jakarta, Indonesia.Children&amp;#039;s Hospital New Orleans, New Orleans, LA, USA.Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA. lqi1@tulane.edu.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. lqi1@tulane.edu.Department of Medicine, Channing Division of Network Medicine, Brigham and Women&amp;#039;s Hospital and Harvard Medical School, Boston, MA, USA. lqi1@tulane.edu.</style></auth-address></record></records></xml>