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M.</style></author><author><style face="normal" font="default" size="100%">Boehnke, M.</style></author><author><style face="normal" font="default" size="100%">Heid, I. M.</style></author><author><style face="normal" font="default" size="100%">Mohlke, K. L.</style></author><author><style face="normal" font="default" size="100%">Strachan, D. P.</style></author><author><style face="normal" font="default" size="100%">Fox, C. S.</style></author><author><style face="normal" font="default" size="100%">Liu, C. T.</style></author><author><style face="normal" font="default" size="100%">Hirschhorn, J. N.</style></author><author><style face="normal" font="default" size="100%">Klein, R. J.</style></author><author><style face="normal" font="default" size="100%">Johnson, A. D.</style></author><author><style face="normal" font="default" size="100%">Borecki, I. B.</style></author><author><style face="normal" font="default" size="100%">Franks, P. W.</style></author><author><style face="normal" font="default" size="100%">North, K. E.</style></author><author><style face="normal" font="default" size="100%">Cupples, L. A.</style></author><author><style face="normal" font="default" size="100%">Loos, R. J. F.</style></author><author><style face="normal" font="default" size="100%">Kilpelainen, T. O.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults</style></title><secondary-title><style face="normal" font="default" size="100%">PLoS GenetPLoS GenetPLoS Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">PLoS genetics</style></alt-title><short-title><style face="normal" font="default" size="100%">PLoS geneticsPLoS genetics</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Exercise</style></keyword><keyword><style  face="normal" font="default" size="100%">Adiposity/*genetics/physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha-Ketoglutarate-Dependent Dioxygenase FTO/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Epigenomics</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome-Wide Association Study</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity/*genetics/physiopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Waist Circumference</style></keyword><keyword><style  face="normal" font="default" size="100%">Waist-Hip Ratio</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Apr</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">4</style></number><edition><style face="normal" font="default" size="100%">2017/04/28</style></edition><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">e1006528</style></pages><isbn><style face="normal" font="default" size="100%">1553-7404 (Electronic)1553-7390 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.</style></abstract><work-type><style face="normal" font="default" size="100%">Meta-Analysis</style></work-type><accession-num><style face="normal" font="default" size="100%">28448500</style></accession-num><notes><style face="normal" font="default" size="100%">Graff, MariaelisaScott, Robert AJustice, Anne EYoung, Kristin LFeitosa, Mary FBarata, LlildaWinkler, Thomas WChu, Audrey YMahajan, AnubhaHadley, DavidXue, LutingWorkalemahu, TsegaselassieHeard-Costa, Nancy Lden Hoed, MarcelAhluwalia, Tarunveer SQi, QibinNgwa, Julius SRenstrom, FridaQuaye, LydiaEicher, John DHayes, James ECornelis, MarilynKutalik, ZoltanLim, EliseLuan, Jian&amp;#039;anHuffman, Jennifer EZhang, WeihuaZhao, WeiGriffin, Paula JHaller, ToomasAhmad, ShafqatMarques-Vidal, Pedro MBien, StephanieYengo, LoicTeumer, AlexanderSmith, Albert VernonKumari, MeenaHarder, Marie NeergaardJustesen, Johanne MarieKleber, Marcus EHollensted, MetteLohman, KurtRivera, Natalia VWhitfield, John BZhao, Jing HuaStringham, Heather MLyytikainen, Leo-PekkaHuppertz, CharlotteWillemsen, GonnekePeyrot, Wouter JWu, YingKristiansson, KatiDemirkan, AyseFornage, MyriamHassinen, MaijaBielak, Lawrence FCadby, GemmaTanaka, ToshikoMagi, Reedikvan der Most, Peter JJackson, Anne UBragg-Gresham, Jennifer LVitart, VeroniqueMarten, JonathanNavarro, PauBellis, ClairePasko, DorotaJohansson, AsaSnitker, SorenCheng, Yu-ChingEriksson, JoelLim, UnheeAadahl, MetteAdair, Linda SAmin, NajafBalkau, BeverleyAuvinen, JuhaBeilby, JohnBergman, Richard NBergmann, SvenBertoni, Alain GBlangero, JohnBonnefond, AmelieBonnycastle, Lori LBorja, Judith BBrage, SorenBusonero, FabioBuyske, SteveCampbell, HarryChines, Peter SCollins, Francis SCorre, TanguySmith, George DaveyDelgado, Graciela EDueker, NicoleDorr, MarcusEbeling, TapaniEiriksdottir, GudnyEsko, TonuFaul, Jessica DFu, MaoFaerch, KristineGieger, ChristianGlaser, SvenGong, JianGordon-Larsen, PennyGrallert, HaraldGrammer, Tanja BGrarup, Nielsvan Grootheest, GerardHarald, KennetHastie, Nicholas DHavulinna, Aki SHernandez, DenaHindorff, LuciaHocking, Lynne JHolmens, Oddgeir LHolzapfel, ChristinaHottenga, Jouke JanHuang, JieHuang, TaoHui, JennieHuth, CorneliaHutri-Kahonen, NinaJames, Alan LJansson, John-OlovJhun, Min AJuonala, MarkusKinnunen, LeenaKoistinen, Heikki AKolcic, IvanaKomulainen, PirjoKuusisto, JohannaKvaloy, KirstiKahonen, MikaLakka, Timo ALauner, Lenore JLehne, BenjaminLindgren, Cecilia MLorentzon, MattiasLuben, RobertMarre, MichelMilaneschi, YuriMonda, Keri LMontgomery, Grant WDe Moor, Marleen H MMulas, AntonellaMuller-Nurasyid, MartinaMusk, A WMannikko, ReijaMannisto, SatuNarisu, NarisuNauck, MatthiasNettleton, Jennifer ANolte, Ilja MOldehinkel, Albertine JOlden, MatthiasOng, Ken KPadmanabhan, SandoshPaternoster, LaviniaPerez, JeremiahPerola, MarkusPeters, AnnettePeters, UlrikePeyser, Patricia AProkopenko, IngaPuolijoki, HannuRaitakari, Olli TRankinen, TuomoRasmussen-Torvik, Laura JRawal, RajeshRidker, Paul MRose, Lynda MRudan, IgorSarti, CinziaSarzynski, Mark ASavonen, KaiScott, William RSanna, SerenaShuldiner, Alan RSidney, SteveSilbernagel, GuntherSmith, Blair HSmith, Jennifer ASnieder, HaroldStancakova, AlenaSternfeld, BarbaraSwift, Amy JTammelin, TuijaTan, Sian-TsungThorand, BarbaraThuillier, DorotheeVandenput, LiesbethVestergaard, Henrikvan Vliet-Ostaptchouk, Jana VVohl, Marie-ClaudeVolker, UweWaeber, GerardWalker, MarkWild, SarahWong, AndrewWright, Alan FZillikens, M CarolaZubair, NihaHaiman, Christopher ALemarchand, LoicGyllensten, UlfOhlsson, ClaesHofman, AlbertRivadeneira, FernandoUitterlinden, Andre GPerusse, LouisWilson, James FHayward, CarolinePolasek, OzrenCucca, FrancescoHveem, KristianHartman, Catharina ATonjes, AnkeBandinelli, StefaniaPalmer, Lyle JKardia, Sharon L RRauramaa, RainerSorensen, Thorkild I ATuomilehto, JaakkoSalomaa, VeikkoPenninx, Brenda W J Hde Geus, Eco J CBoomsma, Dorret ILehtimaki, TerhoMangino, MassimoLaakso, MarkkuBouchard, ClaudeMartin, Nicholas GKuh, DianaLiu, YongmeiLinneberg, AllanMarz, WinfriedStrauch, KonstantinKivimaki, MikaHarris, Tamara BGudnason, VilmundurVolzke, HenryQi, LuJarvelin, Marjo-RiittaChambers, John CKooner, Jaspal SFroguel, PhilippeKooperberg, CharlesVollenweider, PeterHallmans, GoranHansen, TorbenPedersen, OlufMetspalu, AndresWareham, Nicholas JLangenberg, ClaudiaWeir, David RPorteous, David JBoerwinkle, EricChasman, Daniel ICHARGE ConsortiumEPIC-InterAct ConsortiumPAGE ConsortiumAbecasis, Goncalo RBarroso, InesMcCarthy, Mark IFrayling, Timothy MO&amp;#039;Connell, Jeffrey Rvan Duijn, Cornelia MBoehnke, MichaelHeid, Iris MMohlke, Karen LStrachan, David PFox, Caroline SLiu, Ching-TiHirschhorn, Joel NKlein, Robert JJohnson, Andrew DBorecki, Ingrid BFranks, Paul WNorth, Kari ECupples, L AdrienneLoos, Ruth J FKilpelainen, Tuomas OR01 DK093757/DK/NIDDK NIH HHS/K99 HL130580/HL/NHLBI NIH HHS/P30 ES010126/ES/NIEHS NIH HHS/MR/K002414/1/Medical Research Council/United KingdomT32 EY022303/EY/NEI NIH HHS/KL2 TR001109/TR/NCATS NIH HHS/R01 DK072193/DK/NIDDK NIH HHS/MC_UU_12019/1/Medical Research Council/United KingdomS10 OD018522/OD/NIH HHS/R01 HL105756/HL/NHLBI NIH HHS/MC_UU_12015/2/Medical Research Council/United KingdomP30 DK072488/DK/NIDDK NIH HHS/P30 DK020541/DK/NIDDK NIH HHS/UM1 CA182913/CA/NCI NIH HHS/P30 DK020572/DK/NIDDK NIH HHS/S10 OD020069/OD/NIH HHS/P2C HD050924/HD/NICHD NIH HHS/RG/10/12/28456/British Heart Foundation/United KingdomPLoS Genet. 2017 Apr 27;13(4):e1006528. doi: 10.1371/journal.pgen.1006528. eCollection 2017 Apr.</style></notes><custom2><style face="normal" font="default" size="100%">5407576</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.Division of Preventive Medicine, Brigham and Women&amp;#039;s Hospital, Boston, Massachusetts, United States of America.Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.Division of Population Health Sciences and Education, St. George&amp;#039;s, University of London, London, United Kingdom.Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.Steno Diabetes Center, Gentofte, Denmark.Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America.Howard University, Department of Internal Medicine, Washington DC, United States of America.Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden.Department of Biobank Research, Umea University, Umea, Sweden.Department of Twin Research and Genetic Epidemiology, King&amp;#039;s College London, London, United Kingdom.Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, United States of America.Cell and Developmental Biology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York, United States of America.Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.Channing Division of Network Medicine, Department of Medicine, Brigham and Women&amp;#039;s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.Swiss Institute of Bioinformatics, Lausanne, Switzerland.MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.Department of Cardiology, Ealing Hospital HNS Trust, Middlesex, United Kingdom.Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.Estonian Genome Center, University of Tartu, Tartu, Estonia.Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.University of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.Icelandic Heart Association, Kopavogur, Iceland.Faculty of Medicine, University of Iceland, Reykjavik, Iceland.ISER, University of Essex, Colchester, Essex, United Kingdom.Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany.Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.Karolinska Institutet, Respiratory Unit, Department of Medicine Solna, Stockholm, Sweden.Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.EMGO+ Institute, Vrije Universiteit &amp;amp; VU University Medical Center, Amsterdam, The Netherlands.Department of Public and Occupational Health, VU University Medical Center, Amsterdam, The Netherlands.Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.National Institute for Health and Welfare, Department of Health, Helsinki, Finland.Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia, Australia.Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore.Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.Veterans Affairs Maryland Health Care System, University of Maryland, Baltimore, Maryland, United States of America.Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.INSERM U-1018, CESP, Renal and Cardiovascular Epidemiology, UVSQ-UPS, Villejuif, France.Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.Unit of Primary Care, Oulu University Hospital, Oulu, Finland.Busselton Population Medical Research Institute, Nedlands, Western Australia, Australia.PathWest Laboratory Medicine of WA, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia.Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.Texas Biomedical Research Institute, San Antonio, Texas, United States of America.Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines.Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America.Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey, United States of America.Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, Edinburgh, Scotland.MRC Integrative Epidemiology Unit &amp;amp; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.University of Maryland School of Medicine, Department of Epidemiology &amp;amp; Public Health, Baltimore, Maryland, United States of America.Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.Department of Medicine, Oulu University Hospital, Oulu, Finland.Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.Division of Endocrinology, Boston Children&amp;#039;s Hospital, Boston, Massachusetts, United States of America.Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America.Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America.Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Neuherberg, Germany.Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.Institute of Epidemiology II, Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Neuherberg, Germany.German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America.Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom.Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway.Institute for Nutritional Medicine, Klinikum Rechts der Isar, Technische Universitat Munchen, Munich, Germany.NCA Institute, VU University &amp;amp; VU Medical Center, Amsterdam, The Netherlands.Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia.Department of Pediatrics, Tampere University Hospital, Tampere, Finland.Department of Pediatrics, University of Tampere School of Medicine, Tampere, Finland.Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.School of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia, Australia.Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.Department of Medicine, University of Turku, Turku, Finland.Division of Medicine, Turku University Hospital, Turku, Finland.Department of Medicine and Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.Minerva Foundation Institute for Medical Research, Helsinki, Finland.Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland.Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio Campus, Finland.Neuroepidemiology Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.The Big Data Institute, University of Oxford, Oxford, United Kingdom.Geriatric Medicine, Sahlgrenska University Hospital, Molndal, Sweden.Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.INSERM U-1138, Equipe 2: Pathophysiology and Therapeutics of Vascular and Renal diseases Related to Diabetes, Centre de Recherche des Cordeliers, Paris, France.Department of Endocrinology, Diabetology, Nutrition, and Metabolic Diseases, Bichat Claude Bernard Hospital, Paris, France.Center for Observational Research, Amgen Inc., Thousand Oaks, California, United States of America.Section of Clinical Child and Family Studies, Department of Educational and Family Studies, Vrije Universiteit, Amsterdam, The Netherlands.Dipartimento di Scienze Biomediche, Universita degli Studi di Sassari, Sassari, Italy.Department of Medicine I, Ludwig-Maximilians-Universitat, Munich, Germany.DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.University of Tartu, Estonian Genome Centre, Tartu, Estonia.Genomics of Common Disease, Imperial College London, London, United Kingdom.South Ostrobothnia Central Hospital, Seinajoki, Finland.Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.Harvard Medical School, Boston, Massachusetts, United States of America.Social Services and Health Care Department, City of Helsinki, Helsinki, Finland.Division of Research, Kaiser Permanente Northern California, Oakland, California, United States of America.Division of Angiology, Department of Internal Medicine, Medical University Graz, Austria.School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland.LIKES Research Center for Sport and Health Sciences, Jyvaskyla, Finland.National Heart and Lung Institute, Imperial College London, United Kingdom.Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Institute of Nutrition and Functional Foods, Quebec, Canada.School of Nutrition, Laval University, Quebec, Canada.Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany.Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.Centre for Population Health Sciences, Usher Institute for Population Health Sciences and Informatics, Teviot Place, Edinburgh, Scotland.MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.Netherlands Consortium for Healthy Aging, Leiden University Medical Center, Leiden, The Netherlands.Department of Kinesiology, Laval University, Quebec, Canada.Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.University of Leipzig, Medical Department, Leipzig, Germany.Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy.School of Public Health, University of Adelaide, Adelaide, South Australia, Australia.Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.Department of Clinical Epidemiology, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.National Institute for Health Research Biomedical Research Centre at Guy&amp;#039;s and St. Thomas&amp;#039; Foundation Trust, London, United Kingdom.Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.Synlab Academy, Synlab Services LLC, Mannheim, Germany.Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universitat, Munich, Germany.Department of Epidemiology and Public Health, University College London, London, United Kingdom.Laboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, Maryland, United States of America.Biocenter Oulu, University of Oulu, Oulu, Finland.MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom.Imperial College Healthcare NHS Trust, London, United Kingdom.Hammersmith Hospital, London, United Kingdom.Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.Wellcome Trust Sanger Institute, Hinxton, United Kingdom.NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke&amp;#039;s Hospital, Cambridge, United Kingdom.The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom.Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom.Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom.Center of Medical Systems Biology, Leiden, The Netherlands.Population Health Research Institute, St. George&amp;#039;s University of London, London, United Kingdom.Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children&amp;#039;s Hospital, Boston, Massachusetts, United States of America.Department of Public Health &amp;amp; Clinical Medicine, Umea University, Umea, Sweden.Carolina Center for Genome Sciences, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.Genetics of Obesity and Related Metabolic Traits Program, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</style></auth-address></record></records></xml>