<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ding, R.</style></author><author><style face="normal" font="default" size="100%">Huang, T.</style></author><author><style face="normal" font="default" size="100%">Han, J.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Diet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study</style></title><secondary-title><style face="normal" font="default" size="100%">Lipids Health DisLipids Health DisLipids Health Dis</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Lipids in health and disease</style></alt-title><short-title><style face="normal" font="default" size="100%">Lipids in health and diseaseLipids in health and disease</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Smoking Cessation</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha-Ketoglutarate-Dependent Dioxygenase FTO/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes Mellitus, Type 2/etiology/*genetics/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Diet, High-Protein/*adverse effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Life Style</style></keyword><keyword><style  face="normal" font="default" size="100%">Mendelian Randomization Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan 29</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">1</style></number><edition><style face="normal" font="default" size="100%">2018/01/30</style></edition><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">18</style></pages><isbn><style face="normal" font="default" size="100%">1476-511X (Electronic)1476-511X (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND: Observational studies have demonstrated diet/lifestyle play roles in development of type 2 diabetes (T2DM); however, it remains unclear whether these relationships are causal. METHODS: A two-sample MR approach was used to examine the causal effect of diet/lifestyle upon risk of T2DM and glycemic traits. RESULTS: The protein intake-increasing allele C of FTO was significant associated with higher risk of T2DM (Beta +/- SE = 0.104 +/- 0.014, P = 4.40 x 10(- 11)), higher level of HOMA-IR (Beta +/- SE = 0.016 +/- 0.004, P = 9.55 x 10(- 5)), HOMA-B (Beta +/- SE = 0.008 +/- 0.003, P = 0.020). Using MR analyses, increased protein intake was causally associated with an increased risk of T2DM (Beta +/- SE = 0.806 +/- 0.260, P = 0.002). In addition, smoking cessation was causally associated with increased levels of glycemic traits such as HOMA-IR (Beta +/- SE = 0.165 +/- 0.072, P = 0.021), fasting insulin (Beta +/- SE = 0.132 +/- 0.066, P = 0.047) and fasting glucose (Beta +/- SE = 0.132 +/- 0.064, P = 0.039). CONCLUSIONS: These results provide evidence supporting a causal role for higher protein intake and smoking cession in T2DM. Our study provides further rationale for individuals at risk for diabetes to keep healthy lifestyle.</style></abstract><accession-num><style face="normal" font="default" size="100%">29375034</style></accession-num><notes><style face="normal" font="default" size="100%">Ding, RenyuHuang, TaoHan, JialiEnglandLipids Health Dis. 2018 Jan 29;17(1):18. doi: 10.1186/s12944-018-0666-z.</style></notes><custom2><style face="normal" font="default" size="100%">5787924</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Intensive Care Medicine, The First Hospital of China Medical University, Liaoning, 110001, China.Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China. huangtao@bjmu.edu.cn.Department of Otolaryngology, The First Hospital of China Medical University, Liaoning, 110001, China. jiali_han@163.com.</style></auth-address></record></records></xml>