<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Geng, T.</style></author><author><style face="normal" font="default" size="100%">Smith, C. E.</style></author><author><style face="normal" font="default" size="100%">C. Li</style></author><author><style face="normal" font="default" size="100%">Huang, T.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Childhood BMI and Adult Type 2 Diabetes, Coronary Artery Diseases, Chronic Kidney Disease, and Cardiometabolic Traits: A Mendelian Randomization Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Diabetes CareDiabetes CareDiabetes Care</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Diabetes care</style></alt-title><short-title><style face="normal" font="default" size="100%">Diabetes careDiabetes care</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">*Insulin Resistance/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Age Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Child Development/*physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Child, Preschool</style></keyword><keyword><style  face="normal" font="default" size="100%">Coronary Artery Disease/epidemiology/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes Complications/*epidemiology/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes Mellitus, Type 2/*epidemiology/*genetics/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mendelian Randomization Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Renal Insufficiency, Chronic/epidemiology/genetics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">5</style></number><edition><style face="normal" font="default" size="100%">2018/02/28</style></edition><volume><style face="normal" font="default" size="100%">41</style></volume><pages><style face="normal" font="default" size="100%">1089-1096</style></pages><isbn><style face="normal" font="default" size="100%">1935-5548 (Electronic)0149-5992 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">OBJECTIVE: To test the causal effect of childhood BMI on adult cardiometabolic diseases using a Mendelian randomization analysis. RESEARCH DESIGN AND METHODS: We used 15 single nucleotide polymorphisms as instrumental variables for childhood BMI to test the causal effect of childhood BMI on cardiometabolic diseases using summary-level data from consortia. RESULTS: We found that a 1-SD increase in childhood BMI (kg/m(2)) was associated with an 83% increase in risk of type 2 diabetes (odds ratio [OR] 1.83 [95% CI 1.46, 2.30]; P = 2.5 x 10(-7)) and a 28% increase in risk of coronary artery disease (CAD) (OR 1.28 [95% CI 1.17, 1.39]; P = 2.1 x 10(-8)) at the Bonferroni-adjusted level of significance (P &amp;lt; 0.017) in adults. In addition, a 1-SD increase in childhood BMI was associated with a 0.587-SD increase in adulthood BMI (kg/m(2)), a 0.062-SD increase in hip circumference (cm), a 0.602-SD increase in waist circumference (cm), a 0.111 pmol/L increase in log fasting insulin, a 0.068 increase in log-transformed HOMA of ss-cell function (%), a 0.126 increase in log-transformed HOMA of insulin resistance (%), and a 0.109-SD increase in triglyceride (mg/dL) but a 0.138-SD decrease in HDL (mg/dL) in adults at the Bonferroni-adjusted level of significance (P &amp;lt; 0.0026). CONCLUSIONS: A genetic predisposition to higher childhood BMI was associated with increased risk of type 2 diabetes and CAD in adult life. These results provide evidence supportive of a causal association between childhood BMI and these outcomes.</style></abstract><accession-num><style face="normal" font="default" size="100%">29483184</style></accession-num><notes><style face="normal" font="default" size="100%">Geng, TingtingSmith, Caren ELi, ChangweiHuang, TaoDiabetes Care. 2018 May;41(5):1089-1096. doi: 10.2337/dc17-2141. Epub 2018 Feb 26.</style></notes><auth-address><style face="normal" font="default" size="100%">Epidemiology Domain, Saw Swee Hock School of Public Health, National University of Singapore, Singapore.Nutrition and Genomics Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA.Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA.Epidemiology Domain, Saw Swee Hock School of Public Health, National University of Singapore, Singapore huangtao@bjmu.edu.cn.Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.</style></auth-address></record></records></xml>