<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">T. Wang</style></author><author><style face="normal" font="default" size="100%">Heianza, Y.</style></author><author><style face="normal" font="default" size="100%">Sun, D.</style></author><author><style face="normal" font="default" size="100%">Huang, T.</style></author><author><style face="normal" font="default" size="100%">W. Ma</style></author><author><style face="normal" font="default" size="100%">Rimm, E. B.</style></author><author><style face="normal" font="default" size="100%">Manson, J. E.</style></author><author><style face="normal" font="default" size="100%">Hu, F. B.</style></author><author><style face="normal" font="default" size="100%">Willett, W. C.</style></author><author><style face="normal" font="default" size="100%">Qi, L.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Improving adherence to healthy dietary patterns, genetic risk, and long term weight gain: gene-diet interaction analysis in two prospective cohort studies</style></title><secondary-title><style face="normal" font="default" size="100%">BMJBMJ</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Diet/adverse effects/*methods</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Follow-Up Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease/epidemiology/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Health Personnel/statistics &amp; numerical data</style></keyword><keyword><style  face="normal" font="default" size="100%">Healthy Diet/psychology/*trends</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Nurses/statistics &amp; numerical data</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity/epidemiology/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Outcome Assessment (Health Care)</style></keyword><keyword><style  face="normal" font="default" size="100%">Prospective Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment Adherence and Compliance/statistics &amp; numerical data</style></keyword><keyword><style  face="normal" font="default" size="100%">United States/epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Weight Gain/*genetics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan 10</style></date></pub-dates></dates><edition><style face="normal" font="default" size="100%">2018/01/13</style></edition><volume><style face="normal" font="default" size="100%">360</style></volume><pages><style face="normal" font="default" size="100%">j5644</style></pages><isbn><style face="normal" font="default" size="100%">1756-1833 (Electronic)0959-8138 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">OBJECTIVE: To investigate whether improving adherence to healthy dietary patterns interacts with the genetic predisposition to obesity in relation to long term changes in body mass index and body weight. DESIGN: Prospective cohort study. SETTING: Health professionals in the United States. PARTICIPANTS: 8828 women from the Nurses&amp;#039; Health Study and 5218 men from the Health Professionals Follow-up Study. EXPOSURE: Genetic predisposition score was calculated on the basis of 77 variants associated with body mass index. Dietary patterns were assessed by the Alternate Healthy Eating Index 2010 (AHEI-2010), Dietary Approach to Stop Hypertension (DASH), and Alternate Mediterranean Diet (AMED). MAIN OUTCOME MEASURES: Five repeated measurements of four year changes in body mass index and body weight over follow-up (1986 to 2006). RESULTS: During a 20 year follow-up, genetic association with change in body mass index was significantly attenuated with increasing adherence to the AHEI-2010 in the Nurses&amp;#039; Health Study (P=0.001 for interaction) and Health Professionals Follow-up Study (P=0.005 for interaction). In the combined cohorts, four year changes in body mass index per 10 risk allele increment were 0.07 (SE 0.02) among participants with decreased AHEI-2010 score and -0.01 (0.02) among those with increased AHEI-2010 score, corresponding to 0.16 (0.05) kg versus -0.02 (0.05) kg weight change every four years (P&amp;lt;0.001 for interaction). Viewed differently, changes in body mass index per 1 SD increment of AHEI-2010 score were -0.12 (0.01), -0.14 (0.01), and -0.18 (0.01) (weight change: -0.35 (0.03), -0.36 (0.04), and -0.50 (0.04) kg) among participants with low, intermediate, and high genetic risk, respectively. Similar interaction was also found for DASH but not for AMED. CONCLUSIONS: These data indicate that improving adherence to healthy dietary patterns could attenuate the genetic association with weight gain. Moreover, the beneficial effect of improved diet quality on weight management was particularly pronounced in people at high genetic risk for obesity.</style></abstract><work-type><style face="normal" font="default" size="100%">Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov&amp;#039;t</style></work-type><accession-num><style face="normal" font="default" size="100%">29321156</style></accession-num><notes><style face="normal" font="default" size="100%">Wang, TiangeHeianza, YorikoSun, DianjianyiHuang, TaoMa, WenjieRimm, Eric BManson, JoAnn EHu, Frank BWillett, Walter CQi, LuR01 EY015473/EY/NEI NIH HHS/R01 CA049449/CA/NCI NIH HHS/R01 DK100383/DK/NIDDK NIH HHS/R01 DK078616/DK/NIDDK NIH HHS/UM1 CA167552/CA/NCI NIH HHS/R01 HL071981/HL/NHLBI NIH HHS/U01 CA167552/CA/NCI NIH HHS/UM1 CA186107/CA/NCI NIH HHS/EnglandClinical research ed.BMJ. 2018 Jan 10;360:j5644. doi: 10.1136/bmj.j5644.</style></notes><custom2><style face="normal" font="default" size="100%">5759092 at www.icmje.org/coi_disclosure.pdf and declare: no support from any organization for the submitted work other than that described above; no financial relationships with any organizations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work.</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women&amp;#039;s Hospital and Harvard Medical School, Boston, MA, USA.Division of Preventive Medicine, Department of Medicine, Brigham and Women&amp;#039;s Hospital and Harvard Medical School, Boston, MA, USA.Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA lqi1@tulane.edu.</style></auth-address></record></records></xml>